Prognosis of patients with multiple sclerosis associated with uveitis

Marine Martin; Jean-Sébastien Vidal; Caroline Papeix; Thomas Roux; Benedetta Bodini; Céline Louapre; Valérie Touitou; Elisabeth Maillart

doi:10.1016/j.msard.2023.105095

Prognosis of patients with multiple sclerosis associated with uveitis

Mult Scler Relat Disord. 2023 Oct 20:80:105095. doi: 10.1016/j.msard.2023.105095. Online ahead of print.

Authors

Marine Martin¹, Jean-Sébastien Vidal², Caroline Papeix¹, Thomas Roux¹, Benedetta Bodini³, Céline Louapre¹, Valérie Touitou⁴, Elisabeth Maillart⁵

Affiliations

¹ Department of Neurology Pitié-Salpêtrière Hospital, Sorbonne University, APHP-6, 47-83 Boulevard de l'hôpital, Paris, France.
² Assistance Publique, HOPITAUX de Paris, HOPITAUX Universitaires Paris, Hospital Broca, Service de GERIATRIE, University of Paris, Paris/EA 4468, Paris, France.
³ Department of Neurology, saint ANTOINE Hospital, APHP-6, Sorbonne University, Paris, France.
⁴ Department of Ophthalmology, Pitié-Salpêtrière Hospital, DHU Vision and Handicaps, University of Pierre-and-Marie-Curie, Paris 75013, France.
⁵ Department of Neurology Pitié-Salpêtrière Hospital, Sorbonne University, APHP-6, 47-83 Boulevard de l'hôpital, Paris, France. Electronic address: elisabeth.maillart@aphp.fr.

PMID: 39491078
DOI: 10.1016/j.msard.2023.105095

Abstract

Background: Uveitis may be associated with multiple sclerosis (MS) in 1% of cases. Prognosis of this association remains unknown.

Methods: We conducted a retrospective analysis in a cohort of 41 patients with MS (34 relapsing-remitting MS, and 7 secondary progressive MS) matched with 123 controls (MS without uveitis) followed in Department of Neurology, Pitié Salpêtrière Hospital, Paris.

Results: Mean follow-up was 10.1 years (1.0-29.2). Disability accumulation measured as time to reach EDSS 3 was faster in patients with uveitis compared to the control group (p = 0.003) during follow-up.

Conclusions: Our results suggest that uveitis may be associated with a worse MS prognosis.

Keywords: Disability; EDSS; Multiple sclerosis; Prognosis; Uveitis.

Publication types

Letter