Long rod-shaped gallium composite material: Self-separating material aggregation induced enhancement of ROS for photothermal/photodynamic therapy of HCT116 cells

Si-Han Zhou; Rui-Dong Wang; Tian-Tian Wu; Shi-Hui Deng; Ji-Chao Guo; Shu-Min Zhou; Xuan Zhou; Jiajia Du; Qi-Hua Zhao; Xiaoxia Ren; Ming-Jin Xie

doi:10.1016/j.ejmech.2023.115892

Long rod-shaped gallium composite material: Self-separating material aggregation induced enhancement of ROS for photothermal/photodynamic therapy of HCT116 cells

Eur J Med Chem. 2023 Oct 21:262:115892. doi: 10.1016/j.ejmech.2023.115892. Online ahead of print.

Authors

Affiliations

¹ School of Chemical Science and Technology, Yunnan University, Kunming, 650091, Yunnan, China; International Institute of Rivers and Ecological Security, Yunnan University, Kunming, 650091, Yunnan, China.
² School of Chemical Science and Technology, Yunnan University, Kunming, 650091, Yunnan, China.
³ Animal Research and Resource Center, School of Life Sciences, Yunnan University, Kunming, 650091, Yunnan, China.
⁴ School of Chemical Science and Technology, Yunnan University, Kunming, 650091, Yunnan, China. Electronic address: mjxie@ynu.edu.cn.

PMID: 39491428
DOI: 10.1016/j.ejmech.2023.115892

Abstract

As many of the disadvantages of traditional single therapy can be avoided with combination therapy, combination therapy has become a new treatment method. Herein, a long rod-shaped gallium composite multifunctional material (CP-Au-PEG-FA@BSA@IR780) based on chemotherapy therapy (CT), photothermal therapy (PTT) and photodynamic therapy (PDT) is constructed to increase reactive oxygen species (ROS) levels and Au NP release. CP-Au-PEG-FA@BSA@IR780 has fluorescence localization characteristics and can combine with CT-DNA to cause cancer cell apoptosis. The in vitro cytotoxicity experiments showed the excellent biocompatibility and great therapeutic efficacy of the designed nanoplatform compared to those of the IR780 group, which had weak red fluorescence. The in vivo experiments also showed that the designed micro/nano platform can effectively eliminate HCT116 tumors by allowing the temperature of the tumor site to exceed 55 °C (thermal ablation) under light irradiation. The main mechanism of chemotherapy indicated that the presence of Fe²⁺/Fe³⁺ can disrupt the rod-shaped structure of the original material and increase the content of Ga³⁺. Overall, CP-Au-PEG-FA@BSA@IR780 is a promising cancer therapy strategy that combines CT, PTT, and PDT and provides new insights into the synthesis method of enhancing composite materials with photothermal properties.

Keywords: Au NPs; Gallium composite material; HCT116; Photothermal/Photodynamic; ROS.