Impact of Heterogeneous Plaque Deposition on Computed Tomography Derived Fractional Flow Reserve

Echocardiography. 2024 Nov;41(11):e70025. doi: 10.1111/echo.70025.

Abstract

L/P ratio, which indicates the proportion of lumen volume to plaque volume of the vessel, is lower in lesion than in per-lesion (RCA, 0.9 vs. 7.7; LAD, 1.4 vs. 8.1; and LCX, 0.9 vs. 8.0). For lesion located in the middle segments of the three major vessels, FFRCT drops from 0.97 to 0.78 for RCA, from 0.94 to 0.55 for LAD, and from 0.99 to 0.72 for LCX, respectively. Invasive coronary angiography shows moderate stenosis in the middle segment of the RCA but no significant obstructive coronary disease at the sites where FFRCT showed a substantial decline in the LAD and LCX. CCTA indicates coronary CT angiography; ICA, invasive coronary angiography; LAD, left anterior descending artery; LCX, left circumflex artery; RCA, right coronary artery; SOCAD, significant obstructive coronary disease.

Keywords: FFRCT; L/P ratio; coronary artery disease; non‐calcified plaque; plaque.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Computed Tomography Angiography / methods
  • Coronary Angiography* / methods
  • Coronary Artery Disease* / diagnostic imaging
  • Coronary Artery Disease* / physiopathology
  • Coronary Stenosis / diagnostic imaging
  • Coronary Stenosis / physiopathology
  • Coronary Vessels* / diagnostic imaging
  • Coronary Vessels* / physiopathology
  • Female
  • Fractional Flow Reserve, Myocardial* / physiology
  • Humans
  • Male
  • Middle Aged
  • Plaque, Atherosclerotic* / diagnostic imaging
  • Plaque, Atherosclerotic* / physiopathology
  • Reproducibility of Results
  • Tomography, X-Ray Computed / methods