Characterization of the Molecular Signature of Human Monocytes in Aging and Myelodysplastic Neoplasms

Christina Maria Rimpa; Maria Grigoriou; Athanasios Tasis; Nikolaos Paschalidis; Anastasia Filia; Giannis Vatsellas; Panagiotis Papazoglou; Antonios Chatzigeorgiou; Chrysa Kymparidou; Menelaos Papoutselis; Christina Misidou; Theodoros Spyropoulos; Despoina Dimitriou; Haralampos Hatzikirou; Konstantinos Liapis; Eleftheria Lamprianidou; Ioannis Kotsianidis; Ioannis Mitroulis

doi:10.1002/eji.202451387

Characterization of the Molecular Signature of Human Monocytes in Aging and Myelodysplastic Neoplasms

Eur J Immunol. 2024 Nov 8:e202451387. doi: 10.1002/eji.202451387. Online ahead of print.

Authors

Christina Maria Rimpa¹, Maria Grigoriou^{1

2}, Athanasios Tasis¹, Nikolaos Paschalidis², Anastasia Filia^{1

2}, Giannis Vatsellas², Panagiotis Papazoglou¹, Antonios Chatzigeorgiou³, Chrysa Kymparidou¹, Menelaos Papoutselis¹, Christina Misidou¹, Theodoros Spyropoulos¹, Despoina Dimitriou¹, Haralampos Hatzikirou⁴, Konstantinos Liapis¹, Eleftheria Lamprianidou¹, Ioannis Kotsianidis¹, Ioannis Mitroulis¹

Affiliations

¹ Department of Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
² Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
³ Medical School, National and Kapodistrian University of Athens, Athens, Greece.
⁴ Mathematics Department, Khalifa University, Abu Dhabi, UAE.

PMID: 39513195
DOI: 10.1002/eji.202451387

Abstract

• Aging leads to chronic inflammation and immune dysfunction, heightening the risk of myeloid malignancies like MDS and CMML. • Both aging and MDS show alterations in monocyte subtypes and function. Aging boosts inflammatory genes upregulation, whereas MDS favors antigen presentation, reflecting distinct immune and disease-specific adaptations. • MDS shows reduced inflammatory activity in CD14⁺ cells, whereas CMML exhibits heightened inflammation, highlighting distinct disease mechanisms.

Keywords: aging; chronic inflammation; inflammaging; monocytes; myelodysplastic neoplasm (MDS).

Abstract

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