Aromatic polyketides isolated from the marine-derived fungus Didymella aeria and their neuroprotective activity

Hitoshi Kamauchi; Mayu Tanaka; Kakeru Koyama; Yuka Kiba; Masashi Kitamura; Yoshiaki Sugita

doi:10.1007/s11418-024-01858-3

Aromatic polyketides isolated from the marine-derived fungus Didymella aeria and their neuroprotective activity

J Nat Med. 2024 Nov 8. doi: 10.1007/s11418-024-01858-3. Online ahead of print.

Authors

Hitoshi Kamauchi¹, Mayu Tanaka², Kakeru Koyama², Yuka Kiba³, Masashi Kitamura³, Yoshiaki Sugita²

Affiliations

¹ Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyaki-Dai, Sakado, Saitama, 350-0295, Japan. kamauchi@josai.ac.jp.
² Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyaki-Dai, Sakado, Saitama, 350-0295, Japan.
³ School of Pharmacy, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyaki-Dai, Sakado, Saitama, 350-0295, Japan.

PMID: 39514057
DOI: 10.1007/s11418-024-01858-3

Abstract

Two novel aromatic polyketides, penicanesins J and K (1, 2), were isolated from the marine-derived fungus Didymella aeria, along with the known compound integrastatin B (3). The structures of the new compounds were determined by NMR spectroscopy and synthetic methods. The isolated compounds were tested for monoamine oxidase (MAO) B inhibition, anti-amyloid beta (Aβ) aggregation, and protective activity against H₂O₂-induced cell death in human neuroblastoma SH-SY5Y cells. Integrastatin B (3) showed potential activity for inhibition of Aβ aggregation and protection against H₂O₂-induced cell death.

Keywords: Amyloid beta; Aromatic polyketide; Fungal metabolites; SH-SY5Y cells; Tautomerization.