Sec14 proteins in the apicomplexan parasites Plasmodium and Toxoplasma

Florian Lauruol; Dave Richard

doi:10.1016/j.pt.2024.10.018

Sec14 proteins in the apicomplexan parasites Plasmodium and Toxoplasma

Trends Parasitol. 2024 Dec;40(12):1081-1084. doi: 10.1016/j.pt.2024.10.018. Epub 2024 Nov 8.

Authors

Florian Lauruol¹, Dave Richard²

Affiliations

¹ Centre de Recherche en Infectiologie, CRCHU de Québec-Université Laval, Laurier Québec (QC), Canada; Department of Microbiology-Infectious Diseases and Immunology, Faculty of Medicine, Laval University, Quebec City, (Qc), Canada.
² Centre de Recherche en Infectiologie, CRCHU de Québec-Université Laval, Laurier Québec (QC), Canada; Department of Microbiology-Infectious Diseases and Immunology, Faculty of Medicine, Laval University, Quebec City, (Qc), Canada. Electronic address: dave.richard@crchudequebec.ulaval.ca.

PMID: 39521673
DOI: 10.1016/j.pt.2024.10.018

Abstract

Sec14 domain proteins are broadly conserved in eukaryotes and play essential roles in numerous cellular processes. Limited data on Sec14 proteins of apicomplexan parasites suggest that they could be important for their survival. The development of fungi-specific Sec14 inhibitors raises the tantalizing possibility that their apicomplexan counterparts might also be targeted.

Keywords: Plasmodium: Toxoplasma; Sec14; apicomplexan; malaria; phosphoinositides.

MeSH terms

Animals
Plasmodium* / metabolism
Plasmodium* / physiology
Protozoan Proteins* / genetics
Protozoan Proteins* / metabolism
Toxoplasma* / metabolism

Substances

Protozoan Proteins