Genetic predisposition to vaccine-induced immune thrombotic thrombocytopenia

Donald M Arnold; Guillaume Paré; Ishac Nazy

doi:10.1111/bjh.19885

Genetic predisposition to vaccine-induced immune thrombotic thrombocytopenia

Br J Haematol. 2024 Nov 10. doi: 10.1111/bjh.19885. Online ahead of print.

Authors

Donald M Arnold^{1

2}, Guillaume Paré³, Ishac Nazy^{1

2}

Affiliations

¹ Michael G. DeGroote Centre for Transfusion Research, McMaster University, Hamilton, Ontario, Canada.
² Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
³ Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

PMID: 39523606
DOI: 10.1111/bjh.19885

Abstract

Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare prothrombotic disorder with a unique clonality-restricted immunological profile. The study by Petito and Bury et al. provides insight into the role of HLA polymorphisms and an inherent predisposition to VITT. Commentary on: Petito et al. Association of human leucocyte antigen loci with vaccine-induced immune thrombotic thrombocytopenia: Potential role of the interaction between platelet factor 4-derived peptides and MHC-II. Br J Haematol 2024 (Online ahead of print). doi: 10.1111/bjh.19838.

Keywords: HLA; PF4‐derived peptides; clonality‐restricted immunological profile; heparin‐induced thrombocytopenia; vaccine‐induced immune thrombotic thrombocytopenia.