Aphthous lesions turned out to be neonatal very early-onset inflammatory bowel disease: a case report

Felix Hutmacher; Selina Doerig; Rainer Grobholz; Henrik Köhler; Philipp Meyer; Philipp Baumann

doi:10.3389/fped.2024.1433852

Aphthous lesions turned out to be neonatal very early-onset inflammatory bowel disease: a case report

Front Pediatr. 2024 Oct 30:12:1433852. doi: 10.3389/fped.2024.1433852. eCollection 2024.

Authors

Felix Hutmacher^#¹, Selina Doerig^#¹, Rainer Grobholz^{2

3}, Henrik Köhler^{4

5}, Philipp Meyer¹, Philipp Baumann^#¹

Affiliations

¹ Department of Neonatology, Kantonsspital Aarau, Aarau, Switzerland.
² Medical Faculty, University of Zurich, Zurich, Switzerland.
³ Institute of Pathology, Kantonsspital Aarau, Aarau, Switzerland.
⁴ Medical Faculty, University of Basel, Basel, Switzerland.
⁵ Department of Gastroenterology, Kantonsspital Aarau, Aarau, Switzerland.

^# Contributed equally.

Abstract

Neonatal diagnosis of inflammatory bowel disease (IBD) proves challenging due to its non-specific symptoms. A term-born neonate showing states of inflammation and aphthae was treated for sepsis and candidiasis before being diagnosed with interleukin-10 receptor deficiency and consecutive IBD. The patient was finally successfully treated by stem cell transplantation. The case illustrates the difficulties of the diagnostic course in IBD as it may mimic other diseases and emphasizes the importance of considering rare differential diagnoses early in the diagnostic process.

Keywords: candida; case report; inflammatory bowel diseases; newborn; oesophagitis.

Publication types

Case Reports

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. Publication was funded by the Kantonsspital Aarau, Aarau, Switzerland.