Innovation in Botulinum Toxins

Dermatol Clin. 2025 Jan;43(1):55-66. doi: 10.1016/j.det.2024.08.004. Epub 2024 Oct 20.

Abstract

This study aims to analyze and discuss recent trials of high-dose and liquid toxins for treating moderate to severe glabellar lines. A comprehensive review of clinical studies and patient outcomes data was conducted to assess the effectiveness and safety profiles of high-dose and liquid toxins. Clinical studies have demonstrated that high-dose toxins provide prolonged muscle relaxation and reduced wrinkles, with well-tolerated safety profiles. Liquid toxins offer comparable efficacy to traditional formulations with quicker onset and extended duration of effects. The introduction of high-dose and liquid toxins represents a significant advancement in esthetic medicine, providing patients with more options for achieving natural-looking, long-lasting results.

Keywords: Botulinum toxin; Cosmetic dermatology; Esthetic medicine; Glabellar lines; High-dose toxins; Liquid toxins.

Publication types

  • Review

MeSH terms

  • Botulinum Toxins / administration & dosage
  • Botulinum Toxins / therapeutic use
  • Botulinum Toxins, Type A* / administration & dosage
  • Botulinum Toxins, Type A* / therapeutic use
  • Cosmetic Techniques*
  • Forehead
  • Humans
  • Neuromuscular Agents / administration & dosage
  • Neuromuscular Agents / therapeutic use
  • Skin Aging* / drug effects

Substances

  • Botulinum Toxins, Type A
  • Neuromuscular Agents
  • Botulinum Toxins