Chemical Constituents of the Deep-sea Derived Fungus Purpureocillium lilacinum XIA-9

Jia-Xin Duan; Yan-Lin Ma; Zhe-Wen Chen; Zheng-Biao Zou; Rong Chao; You Li; Bao-Fu Li; Yuan Wang; Ying-Ni Pan; Xian-Wen Yang

doi:10.1002/cbdv.202402766

Chemical Constituents of the Deep-sea Derived Fungus Purpureocillium lilacinum XIA-9

Chem Biodivers. 2024 Nov 16:e202402766. doi: 10.1002/cbdv.202402766. Online ahead of print.

Authors

Jia-Xin Duan¹, Yan-Lin Ma², Zhe-Wen Chen³, Zheng-Biao Zou³, Rong Chao³, You Li³, Bao-Fu Li^{1

3}, Yuan Wang³, Ying-Ni Pan¹, Xian-Wen Yang³

Affiliations

¹ School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, China.
² Department of Pharmacy, First People's Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science & Technology, 157 Jinbi Road, Kunming, 650032, China.
³ Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen, 361005, China.

PMID: 39549042
DOI: 10.1002/cbdv.202402766

Abstract

Two new sphingosine derivatives (1 and 2), two new vicinal diol analogs (3 and 4), one new diol analog (5), one new fatty acid (9), together with 19 known compounds (6-8, 10-24), were isolated from Purpureocillium lilacinum XIA-9. Their structures were determined by detailed analysis of the 1D and 2D NMR, HRESIMS, and optical rotatory data. Fusarubin 3-methyl ether (17) exhibited potent inhibition on RSL3 induced ferroptosis with the EC₅₀ value of 0.1 μM.

Keywords: Anti- ferroptosis; Deep-sea fungus; Purpureocillium lilacinum; Sphingosine; Vicinal diol.

Abstract

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