Abstract
The synthesis of a series of alkyl and aryl thioureas (II) starting from 1,3,3-trimethyl-6-azabicyclo[3.2.1]octane is described. Some of alkyl thioureas showed a moderate hypotensive activity in rats. Effects on heart rate and hypoglycemic activity in rats, infiltration anesthesia and antiarrhythmic activity in mice are also reported.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anesthetics, Local / chemical synthesis
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Animals
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Anti-Arrhythmia Agents / chemical synthesis
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Antihypertensive Agents / chemical synthesis*
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Camphanes / chemical synthesis*
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Camphanes / pharmacology
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Chemical Phenomena
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Chemistry
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Heart Rate / drug effects
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Mice
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Rats
Substances
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Anesthetics, Local
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Anti-Arrhythmia Agents
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Antihypertensive Agents
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Camphanes
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1,3,3-trimethyl-6-azabicyclo(3.2.1)octane