Objective: Antiphospholipid antibodies (aPL) are recognized to have a pivotal role in recurrent pregnancy loss (RPL) and cardiovascular disease. Therefore, we assessed the vascular function of women with RPL and examined the association with each type of aPL.
Methods: In this retrospective study, 569 women with RPL and 55 healthy women who had never experienced pregnancy loss were recruited. We performed blood tests for aPL and acceleration plethysmography (APG) to evaluate peripheral vascular function.
Results: The differential pulse wave index (DPI), indicating vascular elasticity, was significantly lower in women with RPL (115.6 ± 4.1) compared to the control group (117.0 ± 2.3). DPI in RPL women with anti-β2 glycoprotein I (aβ2GPI) IgG was significantly lower than those without. Remained blood volume (RBV), indicating post-vasoconstriction blood content, was significantly higher in RPL women with aβ2GI IgG than in those without. Regression analysis showed aβ2GPI IgG and body mass index (BMI) linked negatively with DPI.
Conclusion: Women with RPL have subclinical vascular dysfunction even at reproductive age. It is possible that aβ2GPI IgG is associated with vascular dysfunction in RPL women.
Keywords: accelerated photoplethysmography; antiphospholipid antibodies; anti‐β2 glycoprotein I antibody; recurrent pregnancy loss; vascular dysfunction.
© 2024 The Author(s). International Journal of Gynecology & Obstetrics published by John Wiley & Sons Ltd on behalf of International Federation of Gynecology and Obstetrics.