Solitary fibrous tumor of the prostate with accompanying low-grade prostate cancer

Marie-Lisa Eich; Kira Furlano; Georg Hilfenhaus; Bernhard Ralla; Ulrich Keilholz; Maria Joosten; Damian T Rieke; Thorsten Schlomm; David Horst; Simon Schallenberg

doi:10.1016/j.eucr.2024.102879

Solitary fibrous tumor of the prostate with accompanying low-grade prostate cancer

Urol Case Rep. 2024 Nov 6:57:102879. doi: 10.1016/j.eucr.2024.102879. eCollection 2024 Nov.

Authors

Marie-Lisa Eich¹, Kira Furlano², Georg Hilfenhaus^{3

4}, Bernhard Ralla², Ulrich Keilholz^{3

5}, Maria Joosten¹, Damian T Rieke^{3

6

5}, Thorsten Schlomm², David Horst^{1

5}, Simon Schallenberg¹

Affiliations

¹ Institute of Pathology, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humbolt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
² Department of Urology Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
³ Charité Comprehensive Cancer Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
⁴ Department of Hematology, Oncology and Cancer Immunology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
⁵ German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center, Heidelberg, Germany.
⁶ Department of Hematology, Oncology and Cancer Immunology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Abstract

We present the rare case of a 51-year-old male diagnosed with a solitary fibrous tumor (SFT) of the prostate, along with a concurrent low-grade prostate adenocarcinoma (Gleason score 3 + 3, Grade Group 1). The diagnosis was confirmed by positive immunohistochemical markers, including CD34, BCL2, and STAT6, and molecular analysis showing a NAB2-STAT6 fusion. Following successful surgical management and the simultaneous diagnosis of a pulmonary relapse from a prior thyroid carcinoma, the patient remains under clinical surveillance. This is particularly significant given the patient's history of multiple tumors, including Hodgkin's lymphoma, papillary thyroid carcinoma, prostate cancer, and SFT.

Keywords: Multiple primary cancers; Prostate; Prostate cancer; SFT; Solitary fibrous tumor.

Publication types

Case Reports