Beck Depression Inventory-II Response Following Parathyroidectomy for Primary Hyperparathyroidism: A Systematic Review and Meta-Analyses

Om S Chitnis; Sabrina K Wagner; J Joseph Caraway; Nora L Watson; Rhonda J Allard; Michael I Orestes

doi:10.1002/hed.28003

Beck Depression Inventory-II Response Following Parathyroidectomy for Primary Hyperparathyroidism: A Systematic Review and Meta-Analyses

Head Neck. 2024 Nov 27. doi: 10.1002/hed.28003. Online ahead of print.

Authors

Om S Chitnis¹, Sabrina K Wagner¹, J Joseph Caraway², Nora L Watson³, Rhonda J Allard⁴, Michael I Orestes^{2

5}

Affiliations

¹ F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
² Department of Otolaryngology-Head and Neck Surgery, Walter Reed National Military Medical Center, Bethesda, Maryland, USA.
³ Department of Research Programs, Walter Reed National Military Medical Center, Bethesda, Maryland, USA.
⁴ James A. Zimble Learning Resource Center, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
⁵ Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.

PMID: 39601197
DOI: 10.1002/hed.28003

Abstract

Background: There is currently a lack of consensus regarding neuropsychiatric symptoms as an indication for parathyroidectomy in primary hyperparathyroidism (pHPT). The purpose of this study is to perform a systematic review and meta-analyses of pre- and postoperative Beck Depression Inventory-II (BDI-II) scores in patients with pHPT undergoing parathyroidectomy.

Methods: A search of the literature was performed using Embase, PubMed, Web of Science, PsycINFO, and OvidAll EBM Reviews. Studies were included if they evaluated BDI-II scores in pHPT patients before and after parathyroidectomy.

Results: The literature search returned 1554 studies, of which nine articles met criteria for inclusion. Baseline BDI-II scores were significantly higher in pHPT patients compared to control patients. pHPT patients experienced a statistically significant decrease in BDI-II scores at ≤ 1 and 6 months postoperatively.

Conclusions: Based on the results of this study, a BDI-II score ≥ 14 could potentially advocate for parathyroidectomy in patients with pHPT.

Keywords: BDI‐II; depression; neuropsychiatric symptoms; parathyroidectomy; primary hyperparathyroidism.

Published 2024. This article is a U.S. Government work and is in the public domain in the USA.