Extracellular vesicle therapeutics for cardiac repair

Yilan Hu; Weihang Zhang; Shah Rukh Ali; Koji Takeda; Torsten Peter Vahl; Donghui Zhu; Yi Hong; Ke Cheng

doi:10.1016/j.yjmcc.2024.11.005

Extracellular vesicle therapeutics for cardiac repair

J Mol Cell Cardiol. 2024 Nov 26:199:12-32. doi: 10.1016/j.yjmcc.2024.11.005. Online ahead of print.

Authors

Yilan Hu¹, Weihang Zhang¹, Shah Rukh Ali², Koji Takeda³, Torsten Peter Vahl², Donghui Zhu⁴, Yi Hong⁵, Ke Cheng⁶

Affiliations

¹ Department of Biomedical Engineering, Columbia University, New York, NY 10032, USA.
² Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.
³ Division of Cardiac Surgery, Department of Surgery, Columbia University, New York, NY 10032, USA.
⁴ Department of Biomedical Engineering, College of Engineering and Applied Sciences, Stony Brook University, Stony Brook, NY 11794, USA.
⁵ Department of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA.
⁶ Department of Biomedical Engineering, Columbia University, New York, NY 10032, USA. Electronic address: ke.cheng@columbia.edu.

PMID: 39603560
DOI: 10.1016/j.yjmcc.2024.11.005

Abstract

Extracellular vesicles (EVs) are cell-secreted heterogeneous vesicles that play crucial roles in intercellular communication and disease pathogenesis. Due to their non-tumorigenicity, low immunogenicity, and therapeutic potential, EVs are increasingly used in cardiac repair as cell-free therapy. There exist multiple steps for the design of EV therapies, and each step offers many choices to tune EV properties. Factors such as EV source, cargo, loading methods, routes of administration, surface modification, and biomaterials are comprehensively considered to achieve specific goals. PubMed and Google Scholar were searched in this review, 89 articles related to EV-based cardiac therapy over the past five years (2019 Jan - 2023 Dec) were included, and their key steps in designing EV therapies were counted and analyzed. We aim to provide a comprehensive overview that can serve as a reference guide for researchers to design EV-based cardiac therapies.

Keywords: Bioengineering; Cardiac repair; Extracellular vesicles; Therapeutics.

Publication types

Review