Laser interstitial thermal therapy for hypothalamic-hamartoma-related epilepsy: the long-term cognitive outcome of the first pediatric case in Europe

E Diab; M Lefranc; A G Le Moing; L Hery; E Bourel-Ponchel; P Berquin

doi:10.1007/s00701-024-06256-y

Laser interstitial thermal therapy for hypothalamic-hamartoma-related epilepsy: the long-term cognitive outcome of the first pediatric case in Europe

Acta Neurochir (Wien). 2024 Nov 28;166(1):483. doi: 10.1007/s00701-024-06256-y.

Authors

E Diab^{1

2}, M Lefranc^{3

4}, A G Le Moing^{5

6}, L Hery⁵, E Bourel-Ponchel^{6

7}, P Berquin^{5

6}

Affiliations

¹ Department of Pediatric Neurology, Amiens-Picardie University Medical Center, Amiens, France. diab.eva@chu-amiens.fr.
² CHIMERE Research Unit UR 75 16, Jules Verne University of Picardie, Amiens, France. diab.eva@chu-amiens.fr.
³ CHIMERE Research Unit UR 75 16, Jules Verne University of Picardie, Amiens, France.
⁴ Department of Neurosurgery, Amiens-Picardie University Medical Center, Amiens, France.
⁵ Department of Pediatric Neurology, Amiens-Picardie University Medical Center, Amiens, France.
⁶ INSERM UMR 1105, Research Group On Multimodal Analysis of Brain Function, Jules Verne University of Picardie, Amiens, France.
⁷ Department of Pediatric Neurophysiology, Amiens-Picardie University Medical Center, Amiens, France.

PMID: 39607535
DOI: 10.1007/s00701-024-06256-y

Abstract

Laser interstitial thermal therapy (LITT) is a minimally invasive surgical treatment for drug-resistant, focal epilepsies. With MRI guidance, LITT can also be used to treat hypothalamic hamartoma. Here, we report on the first European case of LITT for hypothalamic hamartoma. No complication occurred except a transitory peripheral facial paralysis. The short- and long term outcomes (for both epilepsy and cognitive development) were excellent.

Keywords: Cognitive development; Gelastic seizures; Hypothalamic hamartoma; Laser interstitial thermal therapy; Stereotactic neurosurgery; Surgery for epilepsy.

MeSH terms

Drug Resistant Epilepsy / etiology
Drug Resistant Epilepsy / surgery
Drug Resistant Epilepsy / therapy
Epilepsy / etiology
Epilepsy / surgery
Europe
Female
Hamartoma* / complications
Hamartoma* / surgery
Humans
Hypothalamic Diseases* / complications
Hypothalamic Diseases* / surgery
Laser Therapy* / methods
Magnetic Resonance Imaging
Male
Treatment Outcome

Supplementary concepts

Hypothalamic hamartomas