Insular Epilepsy: Functions, Diagnostic Approaches, and Surgical Interventions

Felix R Ekman; Jorge A González-Martínez

doi:10.31083/j.jin2311209

Insular Epilepsy: Functions, Diagnostic Approaches, and Surgical Interventions

J Integr Neurosci. 2024 Nov 20;23(11):209. doi: 10.31083/j.jin2311209.

Authors

Felix R Ekman¹, Jorge A González-Martínez²

Affiliations

¹ Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at Gothenburg University, 41390 Gothenburg, Sweden.
² Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.

PMID: 39613468
DOI: 10.31083/j.jin2311209

Abstract

Epilepsy, a chronic neurological disorder characterized by recurrent seizures, affects a significant portion of the global population, with drug-resistant epilepsy (DRE) presenting a major treatment challenge. Insular epilepsy, originating from this complex region, exhibits a broad range of symptoms, making diagnosis particularly difficult. Advanced imaging techniques and invasive procedures like stereoelectroencephalography (SEEG) are often crucial for accurately localizing the epileptogenic zone. Surgical resection remains the primary treatment for DRE, with recent advancements in microsurgical techniques and neuroimaging improving outcomes. Additionally, minimally invasive approaches like laser interstitial thermal therapy (LITT) and radiofrequency thermocoagulation (RFTC) offer promising alternatives.

Keywords: SEEG; diagnostic techniques; insular epilepsy; surgical treatment.

Publication types

Review

MeSH terms

Cerebral Cortex* / diagnostic imaging
Cerebral Cortex* / physiopathology
Cerebral Cortex* / surgery
Drug Resistant Epilepsy* / diagnosis
Drug Resistant Epilepsy* / physiopathology
Drug Resistant Epilepsy* / surgery
Electroencephalography / methods
Epilepsy / diagnosis
Epilepsy / diagnostic imaging
Epilepsy / physiopathology
Epilepsy / surgery
Humans
Neurosurgical Procedures / methods