Spiropyran as Building Block in Peptide Synthesis and Modulation of Photochromic Properties

Org Lett. 2024 Dec 13;26(49):10542-10547. doi: 10.1021/acs.orglett.4c03929. Epub 2024 Dec 2.

Abstract

Light-controlled triggering of materials requires efficient embedding of molecular photoswitches into larger molecules. We herein present the synthesis of two new building blocks for the synthesis of photoswitchable peptides, embedding spiropyranes as a central unit into peptide-backbones via a novel, yet unreported approach. The synthesis presented here allows us to embed spiropyranes directly into solid-phase peptide synthesis (SPPS), further describing the resulting photophysical properties of the as-prepared photoswitchable peptides.

MeSH terms

  • Benzopyrans* / chemical synthesis
  • Benzopyrans* / chemistry
  • Indoles* / chemical synthesis
  • Indoles* / chemistry
  • Molecular Structure
  • Nitro Compounds* / chemical synthesis
  • Nitro Compounds* / chemistry
  • Peptides* / chemical synthesis
  • Peptides* / chemistry
  • Photochemical Processes
  • Solid-Phase Synthesis Techniques

Substances

  • spiropyran
  • Nitro Compounds
  • Benzopyrans
  • Indoles
  • Peptides