Adenovirus Pneumonitis and Disseminated Viremia in a Neonate Successfully Treated With Steroids, Cidofovir and Ecmo

Sampath Jayaweera; Nirmala Sarwan; Swaroop Arghode; Sai S Duraisingham; Ruth Radcliffe; Oliver T R Toovey; Julian W Tang

doi:10.1097/INF.0000000000004670

Adenovirus Pneumonitis and Disseminated Viremia in a Neonate Successfully Treated With Steroids, Cidofovir and Ecmo

Pediatr Infect Dis J. 2025 Jan 7. doi: 10.1097/INF.0000000000004670. Online ahead of print.

Authors

Sampath Jayaweera^{1

2}, Nirmala Sarwan¹, Swaroop Arghode³, Sai S Duraisingham⁴, Ruth Radcliffe^{4

5}, Oliver T R Toovey¹, Julian W Tang^{1

6}

Affiliations

¹ From the Department of Clinical Microbiology, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom.
² Faculty of Medicine and Allied Sciences Rajarata University of Sri Lanka, Saliyapura, Sri Lanka.
³ Paediatric Intensive Care.
⁴ Department of Immunology.
⁵ Department of Paediatrics, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom.
⁶ Department of Respiratory Sciences, University of Leicester, Leicester, United Kingdom.

PMID: 39637314
DOI: 10.1097/INF.0000000000004670

Abstract

A 5-day-old neonate was admitted with chest radiograph showing right-lung opacification. This, together with a severe adenovirus (AdV) viremia (11.8 million copies/mL), indicated severe adenovirus pneumonitis. She was given extracorporeal membrane oxygenation (ECMO), steroids and intravenous cidofovir. After clearing her AdV and 33 days of ECMO, she continued to require nocturnal ventilator support, after transfer back to her local hospital.