Seven diterpenoids including five ent-cleistanthanes (1, 2, 4-6) and two ent-pimaranes (3, 7) were isolated for the first time from the aerial part of Phyllanthus franchetianus H. Lév. Their structures were elucidated on the basis of the extensive spectroscopic analyses, single-crystal X-ray diffraction and ECD analysis. Phyllanthanes A-C (1-3) are new compounds. Notably, the ent-cleistanthanes 1 and 4-5 exhibited moderate cytotoxicity against five human cancer (HL-60, A549, HepG2, MDA-MB-231, SW480) (IC50 = 5.01-32.41 μM) and one normal BEAS-2B (IC50 = 20.45-24.33 μM) cell lines.
Keywords: Cytotoxicity; Ent-Cleistanthane diterpenoids; Ent-Pimarane diterpenoids; Phyllanthus franchetianus.
Copyright © 2024 Elsevier B.V. All rights reserved.