Jatrophane diterpenoids from Jatropha curcas with multidrug resistance reversal activity

Yi-Lin He; Lan-Jun Zhang; Guo-Li Li; Hong-Ying Yang; Lei Zhang; Zheng Gong; Kun Gao

doi:10.1016/j.fitote.2024.106331

Jatrophane diterpenoids from Jatropha curcas with multidrug resistance reversal activity

Fitoterapia. 2024 Dec 3:180:106331. doi: 10.1016/j.fitote.2024.106331. Online ahead of print.

Authors

Yi-Lin He¹, Lan-Jun Zhang², Guo-Li Li³, Hong-Ying Yang¹, Lei Zhang³, Zheng Gong³, Kun Gao⁴

Affiliations

¹ Research Institute, School of Chemistry and Chemical Engineering, Lanzhou Jiaotong University, Lanzhou 730070, People's Republic of China; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.
² State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China; Tea Research Institute, Yunnan Academy of Agricultural Science, Kunming 650201, China.
³ Research Institute, School of Chemistry and Chemical Engineering, Lanzhou Jiaotong University, Lanzhou 730070, People's Republic of China.
⁴ State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China. Electronic address: npchem@lzu.edu.cn.

PMID: 39638074
DOI: 10.1016/j.fitote.2024.106331

Abstract

Nine jatrophane diterpenoids, including six previously undescribed compounds, were extracted and purified from whole plants of Jatropha curcas L. Their structures including absolute configurations were characterized by spectroscopic, quantum chemical Nuclear Magnetic Resonance Spectroscopy, Electronic Circular Dichroism calculation, and Single Crystal X-Ray Diffraction methods. These compounds were evaluated for their ability to reverse multidrug resistance. Among the above compounds, compound 6 showed significant potential as a multidrug resistance modulator, exhibiting higher chemo reversal effects and lower toxicity compared to the positive control verapamil. These findings suggest that compound 6 has promising anticancer properties.

Keywords: Euphorbiaceae; Jatropha curcas L.; Jatrophane diterpenoids; Multidrug resistance reversal activities.