Exercise against nonsmall-cell lung carcinoma: novel insights

Abel Plaza-Florido; Carmen Fiuza-Luces; Alejandro Lucia

doi:10.1016/j.trecan.2024.11.006

Exercise against nonsmall-cell lung carcinoma: novel insights

Trends Cancer. 2024 Dec 4:S2405-8033(24)00261-9. doi: 10.1016/j.trecan.2024.11.006. Online ahead of print.

Authors

Abel Plaza-Florido¹, Carmen Fiuza-Luces², Alejandro Lucia³

Affiliations

¹ Pediatric Exercise and Genomics Research Center, Department of Pediatrics, School of Medicine, University of California Irvine, Irvine, CA, USA. Electronic address: aplazafl@hs.uci.edu.
² Physical Exercise and Pediatric Cancer Research Group, Research Institute of the Hospital 12 de Octubre ('imas12'), Madrid, Spain. Electronic address: cfiuza.imas12@h12o.es.
³ Physical Exercise and Pediatric Cancer Research Group, Research Institute of the Hospital 12 de Octubre ('imas12'), Madrid, Spain; Department of Sport Sciences, Faculty of Medicine, Health and Sports, Universidad Europea de Madrid, Madrid, Spain.

PMID: 39638743
DOI: 10.1016/j.trecan.2024.11.006

Abstract

The mechanisms underlying the potential 'anticancer' effects of exercise remain poorly understood. Luo et al. recently identified an exercise-induced, muscle-derived extracellular vesicle (EV)-associated miR, miR-29a-3p, as a key player in the potential benefits of exercise against nonsmall-cell lung carcinoma (NSCLC), including extracellular matrix (ECM) inhibition and improved antitumoral immune responses.

Keywords: cancer immunotherapy; immune function; omics; oncology; physical activity; tumors.