A post-modified lanthanide metal-organic frameworks as ratiometric luminescent sensor for the visual detection of 5-hydroxytryptamine

Congmin Sun; Xiao Liu; Huimin Zhuo; Xu He; Zerong Ge; Ying Zhang; Zhiqiang Li; Qingqing Xiong

doi:10.1016/j.jhazmat.2024.136793

A post-modified lanthanide metal-organic frameworks as ratiometric luminescent sensor for the visual detection of 5-hydroxytryptamine

J Hazard Mater. 2024 Dec 4:484:136793. doi: 10.1016/j.jhazmat.2024.136793. Online ahead of print.

Authors

Congmin Sun¹, Xiao Liu², Huimin Zhuo¹, Xu He¹, Zerong Ge¹, Ying Zhang¹, Zhiqiang Li³, Qingqing Xiong⁴

Affiliations

¹ School of Chemical Engineering and Technology, Hebei University of Technology, XiPing Dao 5340, Beichen District, Tianjin 300401, PR China.
² School of Chemical Engineering and Technology, Hebei University of Technology, XiPing Dao 5340, Beichen District, Tianjin 300401, PR China; School of Material Science and Engineering, Hebei University of Technology, XiPing Dao 5340, Beichen District, Tianjin 300401, PR China. Electronic address: 2023925@hebut.edu.cn.
³ School of Chemical Engineering and Technology, Hebei University of Technology, XiPing Dao 5340, Beichen District, Tianjin 300401, PR China. Electronic address: zhiqiangli@hebut.edu.cn.
⁴ Department of Hepatobiliary Cancer, Tianjin Medical University Cancer Institute & Hospital, Huanhuxi Road, Hexi District, Tianjin 300060, PR China. Electronic address: xiongqingqing@tmu.edu.cn.

PMID: 39642738
DOI: 10.1016/j.jhazmat.2024.136793

Abstract

5-Hydroxytryptamine (5-HT), a key neurotransmitter, is an important biomarker for carcinoid syndrome. We herein construct a ratiometric luminescent sensor by covalently coupling fluorescein 5-isothiocyanate (FITC) with lanthanide metal-organic frameworks (Ln-MOFs). In the presence of 5-HT, the emission of FITC increases while the emission of Eu^{3 +} decreases, accompanied by a distinct color change of emission from orange to green. This sensor not only has the advantages of high sensitivity (LOD = 0.04 μM), fast response (30 s), excellent selectivity, and large ΔE*_ab value (73), but can also be used for the detection of 5-HT in human serum and allow for instant visual detection with the assistant of smartphone. This ratiometric luminescent sensor offers an alternative avenue for early diagnosis of carcinoid syndrome.

Keywords: 5-hydroxytryptamine; Lanthanide; Metal-organic frameworks; Ratiometric sensing; Visual detection.