There are limited data demonstrating the association of sex with different risks for complications following upper and lower total joint arthroplasty. Therefore, this study set out to determine whether biological sex is associated with different outcomes following primary total shoulder arthroplasty. The Mariner claims database was used to identify patients who underwent primary total joint arthroplasty (TSA) for the treatment of glenohumeral osteoarthritis (OA) between 2005 and 2017. Primary endpoints of the study were to compare frequency of 90-day medical complications between male and female cohorts. This study demonstrates that, within 90 days, TSA males and females do experience significantly different medical complications, specifically, the rate of transfusion of blood products and urinary tract infections (UTIs). This study can be used to evaluate sex-specific risk of medical complications following TSAs. (Journal of Surgical Orthopaedic Advances 33(4):244-246, 2024).