Biofabrication and biomanufacturing in Ireland and the UK

Jack F Murphy; Martha Lavelle; Lisa Asciak; Ross Burdis; Hannah J Levis; Cosimo Ligorio; Jamie McGuire; Marlene Polleres; Poppy O Smith; Lucinda Tullie; Juan Uribe-Gomez; Biqiong Chen; Jonathan I Dawson; Julien E Gautrot; Nigel M Hooper; Daniel J Kelly; Vivian S W Li; Alvaro Mata; Abhay Pandit; James B Phillips; Wenmiao Shu; Molly M Stevens; Rachel L Williams; James P K Armstrong; Yan Yan Shery Huang

doi:10.1007/s42242-024-00316-z

Biofabrication and biomanufacturing in Ireland and the UK

Biodes Manuf. 2024;7(6):825-856. doi: 10.1007/s42242-024-00316-z. Epub 2024 Oct 23.

Authors

Jack F Murphy¹, Martha Lavelle², Lisa Asciak³, Ross Burdis^{4

5}, Hannah J Levis⁶, Cosimo Ligorio^{7

8}, Jamie McGuire⁹, Marlene Polleres¹⁰, Poppy O Smith¹¹, Lucinda Tullie¹², Juan Uribe-Gomez¹³, Biqiong Chen¹⁴, Jonathan I Dawson⁹, Julien E Gautrot¹⁵, Nigel M Hooper^{10

16}, Daniel J Kelly^{17

18

19

20}, Vivian S W Li¹², Alvaro Mata^{7

8

21}, Abhay Pandit¹³, James B Phillips¹¹, Wenmiao Shu³, Molly M Stevens^{4

5

22

23}, Rachel L Williams⁶, James P K Armstrong², Yan Yan Shery Huang¹

Affiliations

¹ Department of Engineering, University of Cambridge, Cambridge, CB2 1PZ UK.
² Department of Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS1 3NY UK.
³ Department of Biomedical Engineering, University of Strathclyde, Glasgow, G4 0NW UK.
⁴ Department of Materials, Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ UK.
⁵ Department of Bioengineering, Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ UK.
⁶ Department of Eye and Vision Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, L7 8TX UK.
⁷ Biodiscovery Institute, University of Nottingham, Nottingham, NG7 2RD UK.
⁸ Department of Chemical and Environmental Engineering, University of Nottingham, Nottingham, NG7 2RD UK.
⁹ Centre for Human Development, Stem Cells and Regeneration, Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, S016 6YD UK.
¹⁰ Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PT UK.
¹¹ UCL Centre for Nerve Engineering, Department of Pharmacology, UCL School of Pharmacy, University College London, London, WC1N 1AX UK.
¹² Stem Cell and Cancer Biology Laboratory, The Francis Crick Institute, London, NW1 1AT UK.
¹³ CÚRAM, SFI Research Centre for Medical Devices, University of Galway, Galway, H91 W2TY Ireland.
¹⁴ School of Mechanical and Aerospace Engineering, Queen's University Belfast, Belfast, BT9 5AH UK.
¹⁵ School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS UK.
¹⁶ Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance and University of Manchester, Manchester, M13 9PL UK.
¹⁷ Trinity Centre for Biomedical Engineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
¹⁸ Department of Mechanical, Manufacturing and Biomedical Engineering, School of Engineering, Trinity College Dublin, Dublin 2, Ireland.
¹⁹ Advanced Materials and Bioengineering Research Centre (AMBER), Royal College of Surgeons in Ireland and Trinity College Dublin, Dublin 2, Ireland.
²⁰ Department of Anatomy and Regenerative Medicine, Royal College of Surgeons in Ireland, Dublin, D02 H903 Ireland.
²¹ School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD UK.
²² Department of Physiology, Anatomy and Genetics, Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, OX1 3QU UK.
²³ Department of Engineering Science, Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, OX1 3QU UK.

Abstract
in English, Chinese

As we navigate the transition from the Fourth to the Fifth Industrial Revolution, the emerging fields of biomanufacturing and biofabrication are transforming life sciences and healthcare. These sectors are benefiting from a synergy of synthetic and engineering biology, sustainable manufacturing, and integrated design principles. Advanced techniques such as 3D bioprinting, tissue engineering, directed assembly, and self-assembly are instrumental in creating biomimetic scaffolds, tissues, organoids, medical devices, and biohybrid systems. The field of biofabrication in the United Kingdom and Ireland is emerging as a pivotal force in bioscience and healthcare, propelled by cutting-edge research and development. Concentrating on the production of biologically functional products for use in drug delivery, in vitro models, and tissue engineering, research institutions across these regions are dedicated to innovating healthcare solutions that adhere to ethical standards while prioritising sustainability, affordability, and healthcare system benefits.

随着我们从第四次工业革命向第五次工业革命的过渡，生物制造领域的兴起正在改变生命科学和医疗保健。3D生物打印、组织工程、定向组装和自组装等先进技术在创建仿生支架、组织类器官、医疗设备和生物系统方面发挥着重要作用。英国和爱尔兰的生物制造领域成为生物科学和医疗保健的关键力量，得益于尖端的研究和发展。这些地区的研究专注于药物输送、体外模型, 类器官,和组织工程的生物功能产品，致力于创新符合伦理标准的医疗保健解决方案，同时支持环保和有效的医疗保健系统。.

Keywords: Biohybrid; Biomaterials; Bioprinting; Drug delivery; Sustainability; Tissue engineering.

Publication types

Review

Abstract in English, Chinese

Publication types

Abstract
in English, Chinese