Divulging the potency of naturally derived photosensitizers in green PDT: an inclusive review Of mechanisms, advantages, and future prospects

Muskan Gupta; Anwesha Sahu; Tuhin Mukherjee; Satyajit Mohanty; Priyamjeet Das; Nikita Nayak; Shivangi Kumari; Ravi Pratap Singh; Ashok Pattnaik

doi:10.1007/s43630-024-00669-5

Divulging the potency of naturally derived photosensitizers in green PDT: an inclusive review Of mechanisms, advantages, and future prospects

Photochem Photobiol Sci. 2024 Dec 10. doi: 10.1007/s43630-024-00669-5. Online ahead of print.

Authors

Muskan Gupta¹, Anwesha Sahu¹, Tuhin Mukherjee¹, Satyajit Mohanty¹, Priyamjeet Das¹, Nikita Nayak¹, Shivangi Kumari¹, Ravi Pratap Singh¹, Ashok Pattnaik²

Affiliations

¹ Division of Pharmacology, Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835215, India.
² Division of Pharmacology, Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835215, India. ashokp@bitmesra.ac.in.

PMID: 39654006
DOI: 10.1007/s43630-024-00669-5

Abstract

Photodynamic Therapy (PDT) offers a minimally invasive approach for treating various health conditions, employing a photosensitizer (PS) and specific light. Recent enhancements make PDT outpatient-friendly and less discomforting. Effectiveness hinges on selecting the appropriate PS. This article delves into natural and synthetic PSs, emphasizing the rising interest in natural alternatives for their safety. It explores their mechanisms, characteristics, and applications, offering insights into their potential contributions to advancing PDT. This extensive review delves into the preclinical and clinical landscape of natural PSs for PDT, shedding light on their diverse applications and promising outcomes. Compounds like curcumin, piperine, riboflavin, psoralen, hypericin, and others show significant potential in preclinical in vitro studies across various cell lines. In vivo, these photosensitizers prove effective against skin tumors, carcinomas, and sarcomas, inducing apoptosis, autophagy, and ROS generation for therapeutic efficacy. The review underscores the critical role of proper dosing and monitoring in balancing therapeutic benefits and risks. It highlights the advantages and limitations of natural PSs, emphasizing their specific targeting, bioavailability, and limited side effects. The future of PDT holds promising breakthroughs, taking from some evidence like Bergamot oil in nanostructured lipid carriers for dermatological conditions. Second-generation photosensitizer Tookad shows potential in prostate cancer treatment, while Tripterygium wilfordii Hook. F. emerges as an antimicrobial PDT source etc. Thus, environmental concerns in PDT prompt a shift to plant extracts for PS purification. The evidence-supported focus on natural PSs establishes this article as a key resource for advancing natural compounds in PDT and their therapeutic applications.

Keywords: Green PDT; Natural alternatives; Photodynamic therapy (PDT); Photosensitizer (PS); Therapeutic efficacy.

Publication types

Review