Pioneering integration of combinatorial chemistry and machine learning to accelerate the development of tailored LNPs for mRNA delivery

Xi He; Pingyu Wang; Linbo Qing; Xiangrong Song

doi:10.1016/j.apsb.2024.08.032

Pioneering integration of combinatorial chemistry and machine learning to accelerate the development of tailored LNPs for mRNA delivery

Acta Pharm Sin B. 2024 Nov;14(11):5079-5081. doi: 10.1016/j.apsb.2024.08.032. Epub 2024 Sep 2.

Authors

Xi He¹, Pingyu Wang², Linbo Qing², Xiangrong Song¹

Affiliations

¹ Department of Critical Care Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041 China.
² College of Electronics and Information Engineering, Sichuan University, Chengdu 610065, China.

No abstract available

Keywords: Combinatorial chemistry; High-throughput screening; High-throughput synthesis; Ionizable lipid; Lipid nanoparticles; Machine learning; mRNA delivery; mRNA therapeutics.