Comparative study of a microdosimetric biological weighting function for RBE10modeling in particle therapy with a solid state SOI microdosimeter

Vladimir A Pan; Alessio Parisi; David Bolst; Jesse Williams; Taku Inaniwa; Michael Jackson; Verity Ahern; Anatoly B Rosenfeld; Linh T Tran

doi:10.1088/1361-6560/ad9f1c

Comparative study of a microdosimetric biological weighting function for RBE₁₀modeling in particle therapy with a solid state SOI microdosimeter

Phys Med Biol. 2025 Jan 7;70(1). doi: 10.1088/1361-6560/ad9f1c.

Authors

Vladimir A Pan¹, Alessio Parisi^{2

3}, David Bolst¹, Jesse Williams¹, Taku Inaniwa⁴, Michael Jackson⁵, Verity Ahern^{6

7}, Anatoly B Rosenfeld¹, Linh T Tran¹

Affiliations

¹ Centre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW 2522, Australia.
² Expert Group in Radiation Protection Dosimetry and Calibration, Belgian Nuclear Research Centre (SCK CEN), Mol 2400, Belgium.
³ Department of Radiation Oncology, Mayo Clinic, Jacksonville 32224, FL, United States of America.
⁴ Department of Accelerator and Medical Physics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
⁵ University of New South Wales, Sydney, Australia.
⁶ Sydney West Radiation Oncology Network, Westmead, Australia.
⁷ Westmead Clinical School, University of Sydney, Sydney, Australia.

PMID: 39671788
DOI: 10.1088/1361-6560/ad9f1c

Abstract

Objective:the recently developed V79-RBE₁₀biological weighting function (BWF) model is a simple and robust tool for a fast relative biological effectiveness (RBE) assessment for comparing different exposure conditions in particle therapy. In this study, the RBE₁₀derived by this model (through the particle and heavy ion transport code system (PHITS) simulatedd(y)spectra) is compared with values of RBE₁₀using experimentally derivedd(y)spectra from a silicon-on-insulator (SOI) microdosimeter.Approach:experimentally measuredd(y)spectra are used to calculate an RBE₁₀value utilizing the V79-RBE₁₀BWF model as well as the modified microdosimetric kinetic model (MKM) to produce an RBE₁₀-vs-y_Dtrend for a wide range of ions. In addition, a beamline specific PHITS simulation was conducted which replicated the exact experimental conditions that were used with the SOI microdosimeter at the heavy ion medical accelerator in Chiba biological beamline with¹²C ions.Main Results:the RBE₁₀-vs-y_Dtrend for¹H,⁴He,⁷Li,¹²C,¹⁴N,¹⁶O,²⁰Ne,²⁸Si,⁵⁶Fe, and¹²⁴Xe ions is examined with good agreement found between the SOI microdosimeter derived RBE₁₀values with the V79-RBE₁₀BWF model and MKM, as well as the PHITS simulations for¹H,⁴He,⁷Li,¹²C,¹⁶O, and⁵⁶Fe ions while some discrepancies were seen for¹⁴N,²⁰Ne, and²⁸Si ions. Deviations have been attributed to the difference in the derivation of thed(y) spectra based on the different methods utilized. Good agreement was found betweeny_Dvalues and an over estimation was observed for RBE₁₀values for the beamline specific simulation of the¹²Cion beam.Significance:overall, this study shows that the SOI microdosimeter is a valuable tool that can be utilized for quick and accurate experimental derivation of thed(y) spectra, which can then be convoluted with the weighting function of the V79-RBE₁₀BWF model to derive RBE₁₀. The SOI microdosimeter is able to derive experimental values ofy_Dand RBE₁₀for various ions in any irradiation condition utilizing other radiobiological models.

Keywords: biological weighting function; microdosimetry; particle therapy; silicon-on-insulator.

Creative Commons Attribution license.

Publication types

Comparative Study

MeSH terms

Radiometry* / instrumentation
Relative Biological Effectiveness*
Silicon

Substances

Silicon