Advances in liquid biopsy: From exploration to practical application

Catherine Alix-Panabières; Klaus Pantel

doi:10.1016/j.ccell.2024.11.009

Advances in liquid biopsy: From exploration to practical application

Cancer Cell. 2024 Nov 28:S1535-6108(24)00444-6. doi: 10.1016/j.ccell.2024.11.009. Online ahead of print.

Authors

Catherine Alix-Panabières¹, Klaus Pantel²

Affiliations

¹ Laboratory of Rare Human Circulating Cells (LCCRH) and Liquid Biopsy, University Medical Centre of Montpellier, Montpellier, France; CREEC (CREES), Unité Mixte de Recherches, IRD 224-CNRS 5290-Université de Montpellier, Montpellier, France; European Liquid Biopsy Society (ELBS), Hamburg, Germany; Department of Tumor Biology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany. Electronic address: c-panabieres@chu-montpellier.fr.
² European Liquid Biopsy Society (ELBS), Hamburg, Germany; Department of Tumor Biology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany. Electronic address: pantel@uke.de.

PMID: 39672165
DOI: 10.1016/j.ccell.2024.11.009

Abstract

Liquid biopsy has received tremendous attention as a non-invasive approach for detecting and tracking cancer. Here, we discuss the latest work on circulating tumor DNA and circulating tumor cells with respect to clinical applications, including cancer screening, early detection of relapse, real-time monitoring of therapeutic efficacy, and detection of therapeutic targets and resistance mechanisms.