Earlier pubertal timing, not tempo, links time-limited early adversity with psychopathology

Mariann A Howland; Brie M Reid; Bonny Donzella; Megan R Gunnar

doi:10.1016/j.ntt.2024.107420

Earlier pubertal timing, not tempo, links time-limited early adversity with psychopathology

Neurotoxicol Teratol. 2024 Dec 11:107:107420. doi: 10.1016/j.ntt.2024.107420. Online ahead of print.

Authors

Mariann A Howland¹, Brie M Reid², Bonny Donzella³, Megan R Gunnar³

Affiliations

¹ Institute of Child Development, University of Minnesota- Twin Cities, Minneapolis, MN, USA. Electronic address: howla042@umn.edu.
² Department of Psychology and Department of Health Sciences, Northeastern University, Boston, MA, USA.
³ Institute of Child Development, University of Minnesota- Twin Cities, Minneapolis, MN, USA.

PMID: 39672392
DOI: 10.1016/j.ntt.2024.107420

Abstract

Evolutionary-developmental theories propose that early adverse experiences adaptively shift the timing (i.e., onset) and tempo (i.e., rate) of pubertal maturation. Empirical evidence of links between early life adversity and pubertal maturation is mixed, potentially in part because isolating the unique impacts of early environments is challenging. The current accelerated longitudinal study used a quasi-experimental design to examine pubertal maturation among 132 previously-institutionalized (PI), internationally adopted children who experienced a time-limited form of severe early life adversity, compared to 169 non-adopted (NA) children. Based on prior literature, we also assessed whether pubertal timing and/or tempo are pathways by which early adversity relates to later symptoms of psychopathology. At each of three annual sessions, Tanner pubertal staging was determined by nurse exam, and symptoms of psychopathology were captured in a composite of child self-reported internalizing and parent-reported externalizing symptoms. Findings revealed that, only among children at Tanner pubertal stages 3 or below, PI children were more likely to have reached stage 3 compared to NA children, reflective of earlier pubertal timing. No group differences were found for pubertal tempo. In the subsample of children at Tanner stage 3 or lower, earlier pubertal timing was an indirect pathway by which early adversity related to both higher levels and greater longitudinal declines in internalizing and externalizing symptoms of psychopathology, accounting for a small proportion of the total effect of early adversity on psychopathology. Results from this quasi-experimental study add to existing research on associations between early adversity, early pubertal timing, and psychopathology, further suggesting that links may be specific to timing but not tempo. While findings broadly align with recent calls to consider early pubertal maturation as a transdiagnostic risk marker with utility for identifying children who could benefit from early mental health intervention, they also suggest that pubertal timing is unlikely to be a robust target for reducing psychopathology risk in these children.

Keywords: Early adversity; Psychopathology; Pubertal timing; Puberty.