Association between brachial-ankle pulse wave velocity, obesity-related indices, and the 10-year incident risk score of atherosclerotic cardiovascular disease: The rural Chinese cohort study

MinQi Gu; DongDong Zhang; YuYing Wu; Xi Li; JinLiang Liang; YaQin Su; Li Yang; TaiFeng Chen; BoTang Guo; Yang Zhao; XueRu Fu; LiuDing Wen; ChuXia Lu; YuKe Chen; WanHe Huang; Pei Qin; FuLan Hu; DongSheng Hu; Ming Zhang

doi:10.1016/j.numecd.2024.103791

Association between brachial-ankle pulse wave velocity, obesity-related indices, and the 10-year incident risk score of atherosclerotic cardiovascular disease: The rural Chinese cohort study

Nutr Metab Cardiovasc Dis. 2024 Nov 12:103791. doi: 10.1016/j.numecd.2024.103791. Online ahead of print.

Authors

MinQi Gu¹, DongDong Zhang², YuYing Wu³, Xi Li³, JinLiang Liang¹, YaQin Su¹, Li Yang¹, TaiFeng Chen¹, BoTang Guo², Yang Zhao³, XueRu Fu³, LiuDing Wen³, ChuXia Lu¹, YuKe Chen¹, WanHe Huang¹, Pei Qin⁴, FuLan Hu¹, DongSheng Hu¹, Ming Zhang⁵

Affiliations

¹ Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen University Medical School, Shenzhen, Guangdong, PR China.
² Department of General Practice, The Affiliated Luohu Hospital of Shenzhen University Medical School, Shenzhen, PR China.
³ Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China.
⁴ Department of Medical Record Management, Shenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen, Guangdong, PR China.
⁵ Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen University Medical School, Shenzhen, Guangdong, PR China. Electronic address: zhangming1720@sina.com.

PMID: 39672744
DOI: 10.1016/j.numecd.2024.103791

Abstract

Background and aims: Although existing evidence suggests that arterial stiffness and obesity impact cardiovascular health, limited studies have been conducted to explore the association between brachial-ankle pulse wave velocity (baPWV), obesity-related indices, and the risk of atherosclerotic cardiovascular disease (ASCVD).

Methods and results: The study participants were among those who completed the baPWV measurement at the second follow-up examination (during 2018-2020) of the Rural Chinese Cohort Study. Logistic regression models were employed to calculate odds ratios (ORs) and 95 % confidence intervals (CIs) of the 10-year incident risk score of ASCVD associated with baPWV and obesity-related indices. Mediation analysis was applied to investigate the role of baPWV in the obesity-induced 10-year incident risk score of ASCVD. A total of 1589 individuals, including 573 men and 1016 women, were included in the study. In logistic regression analyses, the highest quartile levels of baPWV and obesity-related indices all significantly increased the 10-year incident risk score of ASCVD compared to their corresponding lowest quartiles. The ORs (95%CIs) of ASCVD 10-year incident risk score risk were 4.21(2.55-6.94) for baPWV, 4.43(2.69-7.29) for METS-VF, 7.20(4.09-12.66) for CVAI, 3.38(2.12-5.38) for CI, and 2.40(1.54-3.75) for ABSI. The indirect effect of baPWV accounted for 5.85 %, 7.92 %, 14.56 %, and 5.08 % of the total effects for METS-VF, CVAI, CI, and ABSI, respectively.

Conclusion: This study found that elevated levels of both baPWV and obesity-related indices were associated with a higher 10-year incident risk score of ASCVD. Additionally, baPWV partially mediated the obesity-related increase in 10-year incident risk score of ASCVD.

Keywords: Atherosclerotic cardiovascular disease; Brachial-ankle pulse wave velocity; Cross-sectional; Mediation; Obesity.

Copyright © 2024 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.