Diagnosing Respiratory Variability: Convolutional Neural Networks for Chest X-ray Classification Across Diverse Pulmonary Conditions

Rajesh Kancherla; Anju Sharma; Prabha Garg

doi:10.1007/s10278-024-01355-9

Diagnosing Respiratory Variability: Convolutional Neural Networks for Chest X-ray Classification Across Diverse Pulmonary Conditions

J Imaging Inform Med. 2024 Dec 13. doi: 10.1007/s10278-024-01355-9. Online ahead of print.

Authors

Rajesh Kancherla¹, Anju Sharma¹, Prabha Garg²

Affiliations

¹ Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research, S. A. S. Nagar, Punjab, 160062, India.
² Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research, S. A. S. Nagar, Punjab, 160062, India. prabhagarg@niper.ac.in.

PMID: 39673008
DOI: 10.1007/s10278-024-01355-9

Abstract

The global burden of lung diseases is a pressing issue, particularly in developing nations with limited healthcare access. Accurate diagnosis of lung conditions is crucial for effective treatment, but diagnosing lung ailments using medical imaging techniques like chest radiograph images and CT scans is challenging due to the complex anatomical intricacies of the lungs. Deep learning methods, particularly convolutional neural networks (CNN), offer promising solutions for automated disease classification using imaging data. This research has the potential to significantly improve healthcare access in developing countries with limited medical resources, providing hope for better diagnosis and treatment of lung diseases. The study employed a diverse range of CNN models for training, including a baseline model and transfer learning models such as VGG16, VGG19, InceptionV3, and ResNet50. The models were trained using image datasets sourced from the NIH and COVID-19 repositories containing 8000 chest radiograph images depicting four lung conditions (lung opacity, COVID-19, pneumonia, and pneumothorax) and 2000 healthy chest radiograph images, with a ten-fold cross-validation approach. The VGG19-based model outperformed the baseline model in diagnosing lung diseases with an average accuracy of 0.995 and 0.996 on validation and external test datasets. The proposed model also outperformed published lung-disease prediction models; these findings underscore the superior performance of the VGG19 model compared to other architectures in accurately classifying and detecting lung diseases from chest radiograph images. This study highlights AI's potential, especially CNNs like VGG19, in improving diagnostic accuracy for lung disorders, promising better healthcare outcomes. The predictive model is available on GitHub at https://github.com/PGlab-NIPER/Lung_disease_classification .

Keywords: COVID-19; Lung diseases; Lung opacity; Neural networks; Pneumonia; Pneumothorax.