Introduction: Extramedullary disease (EMD) is a rare manifestation of Waldenström macroglobulinemia (WM), and its clinical and prognostic implications are poorly understood.
Methods: In this single-center study, we investigated the clinical significance of EMD in a cohort of 469 WM patients.
Results: EMD was identified in 30 (6.4%) patients, with the central nervous system, kidneys, and lungs being the most frequently affected sites. The cumulative incidence of EMD was 12.6% at 15 years. Median overall survival rates at 5 and 10 years for patients with EMD were 63% and 37%, respectively.
Conclusion: Our findings indicate a persistent risk of EMD throughout the disease course, with no significant impact on long-term survival.
Keywords: Waldenström macroglobulinemia; extramedullary; extranodal; lymphoplasmacytic lymphoma; prognosis.
© 2024 The Author(s). eJHaem published by British Society for Haematology and John Wiley & Sons Ltd.