Letter to the Editor: Spatial proximity of tumor-immune interactions predicts patient outcome in hepatocellular carcinoma

Gaoyao Peng; Jiangfa Li; Xinchou Wang

doi:10.1007/s12672-024-01666-x

Letter to the Editor: Spatial proximity of tumor-immune interactions predicts patient outcome in hepatocellular carcinoma

Discov Oncol. 2024 Dec 18;15(1):763. doi: 10.1007/s12672-024-01666-x.

Authors

Gaoyao Peng^{1

2}, Jiangfa Li³, Xinchou Wang^{4

5}

Affiliations

¹ Department of Breast Surgery, Guilin Women's and Children's Hospital, No. 20, Fengbei Road, Guilin, China.
² Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical University, Xiufen District, No. 15, Lequn Road, Guilin, 541001, Guangxi, China.
³ Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical University, Xiufen District, No. 15, Lequn Road, Guilin, 541001, Guangxi, China. 247546160@qq.com.
⁴ Department of Breast Surgery, Guilin Women's and Children's Hospital, No. 20, Fengbei Road, Guilin, China. 984200027@qq.com.
⁵ Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical University, Xiufen District, No. 15, Lequn Road, Guilin, 541001, Guangxi, China. 984200027@qq.com.

Abstract

We read with interest the study entitled "Spatial proximity of tumor-immune interactions predicts patient outcome in hepatocellular "in Hepatology (Maestri E, Kedei N, Khatib S, et al. in Hepatology 79(4):768-79, 2024). This study utilized highly multiplexed CODEX imaging to comprehensively analyze the spatial interactions between tumor and immune cells in hepatocellular carcinoma (HCC), yielding several meaningful findings and innovatively proposing the concept of the spatial neighborhood of immune cell infiltration and confirming its association with patient prognosis. After reading the article carefully, we have some suggestions to point out.

Publication types

Letter