Skeletal Stem Cells: A Basis for Orthopaedic Pathology and Tissue Repair

Ting Cong; Kyle W Morse; Branden R Sosa; Joseph M Lane; Scott A Rodeo; Matthew B Greenblatt

doi:10.2106/JBJS.24.00905

Skeletal Stem Cells: A Basis for Orthopaedic Pathology and Tissue Repair

J Bone Joint Surg Am. 2024 Dec 18. doi: 10.2106/JBJS.24.00905. Online ahead of print.

Authors

Ting Cong^{1

2}, Kyle W Morse^{3

4}, Branden R Sosa^{3

4}, Joseph M Lane^{3

4}, Scott A Rodeo^{3

4}, Matthew B Greenblatt^{5

6}

Affiliations

¹ Department of Orthopaedic Surgery, UPMC Sports Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
² Department of Orthopedic Surgery, VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania.
³ Hospital for Special Surgery, New York, NY.
⁴ Department of Orthopaedic Surgery, Weill Cornell Medicine, New York, NY.
⁵ Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY.
⁶ Research Division, Hospital for Special Surgery, New York, NY.

PMID: 39693451
DOI: 10.2106/JBJS.24.00905

Abstract

➢ Skeletal stem cells (SSCs) continually replenish mature cell populations to support skeletal homeostasis.➢ SSCs repopulate by self-renewal, have multilineage potential, and are long-lived in vivo.➢ SSCs express specific combinations of cell surface markers that reflect their lineage identity.➢ SSCs adapt to their anatomic environment to support regional differences in skeletal behavior and pathology.