Acute Liver Failure Caused by Isoniazid during Preventive Treatment for Latent Tuberculosis: A Rare Autopsy Case Report

Yuka Yamazaki; Keiichi Tominaga; Takahiro Arisaka; Mayuko Tagaya; Shunsuke Kojimahara; Toshihiko Ohnishi; Yuichi Majima; Akira Yamamiya; Makoto Iijima; Naoya Ikeda; Seiji Niho; Shuhei Noda; Kazuyuki Ishida; Atsushi Irisawa

doi:10.2169/internalmedicine.4720-24

Acute Liver Failure Caused by Isoniazid during Preventive Treatment for Latent Tuberculosis: A Rare Autopsy Case Report

Intern Med. 2024 Dec 19. doi: 10.2169/internalmedicine.4720-24. Online ahead of print.

Affiliations

¹ Department of Gastroenterology, Dokkyo Medical University School of Medicine, Japan.
² Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Japan.
³ Department of Diagnostic Pathology, Dokkyo Medical University School of Medicine, Japan.

PMID: 39694482
DOI: 10.2169/internalmedicine.4720-24

Abstract

Treating patients with latent tuberculosis infection (LTBI) to prevent the development of tuberculosis is a fundamental treatment strategy in daily practice. Isoniazid (INH) therapy for 6-12 months is recommended. However, INH can also cause hepatotoxicity. This report describes the autopsy case of a 65-year-old Japanese man diagnosed with LTBI who died of acute liver failure caused by INH.

Keywords: acute liver failure; autopsy; isoniazid; latent tuberculosis infection; tuberculosis.