The association of RBP4 with chronic kidney diseases in southern Chinese population

Front Endocrinol (Lausanne). 2024 Dec 4:15:1381060. doi: 10.3389/fendo.2024.1381060. eCollection 2024.

Abstract

Background: Retinol binding protein 4 (RBP4), as a novel adipokine, has been proven to be highly related to insulin resistance, obesity, diabetes, hypertension, hyperuricemia and other metabolic diseases, which are all risk factors for chronic kidney disease (CKD). However, there is a lack of sufficient studies to explore the relationship between RBP4 and CKD, and no reports have described the predictive value of RBP4 for CKD. This study was designed to clarify the relationship between RBP4 and CKD and its potential predictive value.

Methods: Our team has conducted a large-scale cross-sectional survey that contained 2117 individuals on the southern coast of China. Correlation test, logistic regression analysis were used to evaluate the association between RBP4 and CKD. Receiver operating characteristic (ROC) were used to evaluate the optimal cut-off and predictive value of RBP4 for predicting CKD.

Results: By using the quartile grouping method, the population was divided into four groups according to the RBP4 level. As the RBP4 level increased, the prevalence of CKD also gradually increased among different groups. RBP4 was also correlated with various metabolic risk factors, such as blood glucose, blood lipids, blood pressure, waist circumference, uric acid, and with kidney function indicators such as creatinine, urine protein. Logistic regression analysis found that after adjusting for confounders, RBP4 remained significantly associated with CKD, independent of metabolic risk factors. ROC analysis showed that RBP4 as a single index, AUC (0.666) was superior to Scr, FBG, Log HOMA-IR, WC, TG, VLDL-C, UA, HDL-C, LDL-C, and that combining RBP4 indicator and other common risk factors of CKD can improve the accuracy for predicting CKD.

Conclusion: This study found that the RBP4 was strongly correlated with CKD, RBP4 may become a valuable marker and have strong power for predicting CKD.

Keywords: chronic kidney disease; cross-sectional survey; insulin resistance; metabolic disorder; retinol binding protein 4(RBP4).

MeSH terms

  • Adult
  • Aged
  • Biomarkers / blood
  • China / epidemiology
  • Cross-Sectional Studies
  • East Asian People
  • Female
  • Humans
  • Male
  • Middle Aged
  • Renal Insufficiency, Chronic* / blood
  • Renal Insufficiency, Chronic* / complications
  • Renal Insufficiency, Chronic* / epidemiology
  • Retinol-Binding Proteins, Plasma* / metabolism
  • Risk Factors

Substances

  • Retinol-Binding Proteins, Plasma
  • RBP4 protein, human
  • Biomarkers

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by Shenzhen Basic Research Program General Program (Project No.JCYJ202308071141000001 2024SC0036), Municipal Science and Technology Innovation Commission University Stability Support Project (Project No.2020082 2123122001) and also supported by Key technical projects of the Municipal Science and Technology Innovation Commission (Project No.JSGG2020022515 2709802) and National Natural Science Fund (Project No. 81873620), and also supported by Provincial Natural Science Fund (Project No.2021A151501 0972).