Photoinduced SF6 degradation for deoxyfluorination of propargyl alcohols

Org Biomol Chem. 2024 Dec 19. doi: 10.1039/d4ob01839g. Online ahead of print.

Abstract

Deoxyfluorination is one of the most practical methods for introducing fluorine atoms, since hydroxyl groups are commonly found in organic small molecules. Traditional fluorination methods often rely on hazardous fluorinating reagents. Herein, we report the deoxyfluorination of propargyl alcohols using sulfur hexafluoride (SF6) as a safe fluorinating agent under photocatalytic conditions.