Effective Hydrogel Vascular Patch Dual-Loaded with Cycloastragenol Nanostructured Lipid Carriers and Doxycycline for Repairing Extravascular Injury in Abdominal Aortic Aneurysm

Du Chen; Tiantian Song; Yi Liu; Ying Wang; Boyang Qin; Qingyi Zhang; Weipeng Hu; Xiqiao Zhou; Rong Qi

doi:10.1002/adhm.202402497

Effective Hydrogel Vascular Patch Dual-Loaded with Cycloastragenol Nanostructured Lipid Carriers and Doxycycline for Repairing Extravascular Injury in Abdominal Aortic Aneurysm

Adv Healthc Mater. 2024 Dec 20:e2402497. doi: 10.1002/adhm.202402497. Online ahead of print.

Authors

Du Chen^{1

2

3}, Tiantian Song^{1

2}, Yi Liu⁴, Ying Wang^{1

2

3}, Boyang Qin^{1

2}, Qingyi Zhang^{1

2}, Weipeng Hu^{1

2}, Xiqiao Zhou^{1

2}, Rong Qi^{1

2

3}

Affiliations

¹ Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing, 100191, China.
² State Key Laboratory of Vascular Homeostasis and Remodeling. NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China.
³ School of Pharmacy ／ Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, Shihezi University, Shihezi, 832003, China.
⁴ School of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology, Guangzhou, 511442, China.

PMID: 39703126
DOI: 10.1002/adhm.202402497

Abstract

Endovascular aneurysm repair (EVAR) plays a crucial role in the treatment of abdominal aortic aneurysm (AAA) in the clinic, but the aneurysm remains in the patient's body after surgery, continuing to pose a risk of progression. Cycloastragenol (CAG) is proven to be an effective anti-AAA drug, and its vascular protective effects can be further improved when the hydrophobic CAG is encapsulated into nano-sized formulations to enhance its bioavailability. In this context, this study developed an extravascular patch hydrogel loaded with CAG nanostructured lipid carriers and a hydrophilic drug of doxycycline hydrochloride (DOX). The extravascular patch delivered onto the mouse abdominal aortas can promote local permeation of hydrophilic/hydrophobic drugs at the vessel sites and provide effective vascular protection against AAA injury induced by elastase. This study introduces a novel and promising approach for AAA treatment, which can serve as a supplementary strategy after EVAR surgery.

Keywords: abdominal aortic aneurysm; cycloastragenol; doxycycline; hydrogel; nanostructured lipid carriers.

Abstract

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