D-aring to explore: New approaches to gasdermin D targeting

Lei Wang; Wen Zhou

doi:10.1016/j.chembiol.2024.11.006

D-aring to explore: New approaches to gasdermin D targeting

Cell Chem Biol. 2024 Dec 19;31(12):2015-2017. doi: 10.1016/j.chembiol.2024.11.006.

Authors

Lei Wang¹, Wen Zhou²

Affiliations

¹ Department of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China. Electronic address: wangl6@sustech.edu.cn.
² Department of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China; Shenzhen Key Laboratory of Biomolecular Assembling and Regulation, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China. Electronic address: zhouw@sustech.edu.cn.

PMID: 39706165
DOI: 10.1016/j.chembiol.2024.11.006

Abstract

Novel inhibitors of pyroptosis promise breakthroughs in treating inflammatory diseases and malignant tumors. In this issue of Cell Chemical Biology, Hu et al.¹ identify two repurposed drugs that selectively target gasdermin D (GSDMD) oligomers, effectively suppressing pyroptosis while reducing off-target effects typical of cysteine-based inhibitors.

MeSH terms

Gasdermins
Humans
Intracellular Signaling Peptides and Proteins* / antagonists & inhibitors
Intracellular Signaling Peptides and Proteins* / metabolism
Phosphate-Binding Proteins* / antagonists & inhibitors
Phosphate-Binding Proteins* / metabolism
Pyroptosis* / drug effects

Substances

Phosphate-Binding Proteins
Intracellular Signaling Peptides and Proteins
GSDMD protein, human
Gasdermins