The increase in the expression of circRNAs may contributes to a poor prognosis in acute myeloid leukemia: A systematic review and meta-analysis

Meng Li; Shiming Zhang; Junfan Wei; Mengfei Liu; Bohao Zhang; Shen Li; Yue Xiao; Yuandong Yu; Ruipeng Song

doi:10.1016/j.leukres.2024.107639

The increase in the expression of circRNAs may contributes to a poor prognosis in acute myeloid leukemia: A systematic review and meta-analysis

Leuk Res. 2024 Dec 18:148:107639. doi: 10.1016/j.leukres.2024.107639. Online ahead of print.

Authors

Meng Li¹, Shiming Zhang², Junfan Wei³, Mengfei Liu², Bohao Zhang⁴, Shen Li⁵, Yue Xiao¹, Yuandong Yu⁶, Ruipeng Song⁷

Affiliations

¹ Nursing Department, The Third People's Hospital of Henan Province, Zhengzhou, China.
² Department of Clinical Medicine, Xiamen Medical College, Xiamen, China.
³ Seventh Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
⁴ Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
⁵ School of Rehabilitation, Henan Vocational College of Tuina, Luoyang, China.
⁶ Department of Health Management Center, The Third People's Hospital of Henan Province, Zhengzhou, China.
⁷ Endocrinology Department, The Third People's Hospital of Henan Province, China. Electronic address: 19835611602@163.com.

PMID: 39708434
DOI: 10.1016/j.leukres.2024.107639

Abstract

Objective: The primary methods for defining the prognostic risk of AML patients are cytogenetic and molecular analysis at the time of diagnosis. However, the prognosis of intermediate-risk patients is still not well assessed for biomarkers. The main objective of this meta-analysis is to evaluate the relationship between circRNAs and AML prognosis, to provide a theoretical basis for finding effective prognostic indicators in intermediate-risk patients, and to provide an important scientific basis for the development or revision of WHO practice guidelines and ELN risk classification, and to highlight the importance of continuing to focus on and evaluate the prognostic impact of circRNAs on AML in future studies.

Methods: We performed a comprehensive literature search across PubMed, the Cochrane Library, and Web of Science databases for studies published up to September 15, 2024. Articles were selected based on inclusion criteria. The Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of studies. The outcome measure of overall survival (OS) was used, and hazard ratios (HR) and 95 % confidence intervals (CI) were pooled to estimate the relationship between circRNA expression and prognosis in AML using STATA 17.0 software.

Results: A total of 13 studies involving 1401 AML patients were included. The studies showed a significantly increased hazard ratio (HR) of upregulated CircRNA expression for OS (HR=1.87, 95 % CI=1.51-2.32, P < 0.001). The results of subgroups analysis showed a significant increase in the hazard ratio (HR) for upregulation of CircRNA expression in EFS and circ_0012152（HR= 1.66, 95 % CI= 1.19-2.32, P < 0.005 and HR= 2.26,95 % CI= 1.27-4.00, P < 0.005), respectively. No significant heterogeneity or publication bias was detected.

Conclusion: Upregulated circRNA expression is significantly associated with poor prognosis in AML patients and may serve as a prognostic marker for AML.

Keywords: Acute myeloid leukemia; CircRNA; Meta-analysis; Prognosis.