Preparation of antibacterial cellulose nanocrystals-graft-poly[2-(tert-butylamino) ethyl methacrylate] nanoparticles and their applications on creating wound dressings with a bacterial shielding property

Zheng-Ian Lin; Yi-Ling Wu; Yu-Min Wang; Wen-Shin Ke; Hsin-Yu Lin; Chih-Kuang Chen

doi:10.1016/j.ijbiomac.2024.138994

Preparation of antibacterial cellulose nanocrystals-graft-poly[2-(tert-butylamino) ethyl methacrylate] nanoparticles and their applications on creating wound dressings with a bacterial shielding property

Int J Biol Macromol. 2024 Dec 19:138994. doi: 10.1016/j.ijbiomac.2024.138994. Online ahead of print.

Authors

Zheng-Ian Lin¹, Yi-Ling Wu¹, Yu-Min Wang¹, Wen-Shin Ke¹, Hsin-Yu Lin¹, Chih-Kuang Chen²

Affiliations

¹ Polymeric Biomaterials Laboratory, Department of Materials and Optoelectronic Science, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.
² Polymeric Biomaterials Laboratory, Department of Materials and Optoelectronic Science, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan. Electronic address: chihkuan@mail.nsysu.edu.tw.

PMID: 39708857
DOI: 10.1016/j.ijbiomac.2024.138994

Abstract

Bacterial infections in wounds, especially in patients with chronic conditions like diabetic wounds, pose significant treatment challenges. Addressing the susceptibility to infection is crucial, and the development of functional dressings to prevent bacterial invasion has proven a promising strategy. Cellulose nanocrystals (CNCs), derived from bio-resources and functioning as nanoparticles (NPs), were modified with poly[2-(tert-butylamino) ethyl methacrylate] (PTA) through atom transfer radical polymerization (ATRP) to create CNCs-graft-PTA NPs (CNPs). Optimized CNPs exhibited enhanced antibacterial efficacy, excellent dispersity in environmentally friendly solvents, and notable biocompatibility. These CNPs were then applied to polypropylene non-woven fabrics (PP_NWFs) via a straightforward dipping procedure. The integration of CNPs onto PP_NWFs endowed them with exceptional antibacterial properties, a remarkable ability to shield against bacterial intrusion, and demonstrated biosafety through in vitro and in vivo assessments. With their desirable biomedical characteristics, CNP-modified PP_NWFs emerge as a promising choice for the top layer in various functional dressings aimed at effectively treating wounds prone to infection.

Keywords: Antibacterial cellulose nanocrystals; Antibacterial non-woven fabrics; Bacterial shielding dressings; Bacterial-infected wounds; Poly[2-(tert-butylamino) ethyl methacrylate].