Background: Allergic contact dermatitis cannot be reliably differentiated from other forms of spongiotic/eczematous dermatitis by histology alone. Textbooks and recent studies have variably supported the specificity of dermal eosinophils, eosinophilic spongiosis, and Langerhans cell collections, among other features.
Objective: To assess which histopathologic features favor a diagnosis of allergic contact dermatitis.
Methods: In this case control study with prospective validation, patients were evaluated by patch testing and skin biopsy. Lesional histopathologic features were independently assessed.
Results: 170 cases fulfilled inclusion criteria. Langerhans cell collections were more likely to be found in allergic contact dermatitis (29/111, 26%)(p = 0.03). Heavy dermal eosinophilic infiltration was associated with diagnoses other than allergic contact dermatitis. No significant differences were found for any other predictor variables.
Limitations: Mostly retrospective study with small validation sample.
Conclusion: This largest study to date is the first to independently confirm Langerhans cell collections as the single histopathologic feature most closely associated with allergic contact dermatitis.
Keywords: Langerhans cell collections; Langerhans cells; allergic contact dermatitis; dermatitis; dermatopathology; diagnosis; eczema; eosinophilic spongiosis; eosinophils; patch test; spongiosis; spongiotic dermatitis.
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