Dietary B vitamins influence the Drosophila melanogaster preference for dietary yeast

Dean B Peterson; John Chaston; Andrew T Call

doi:10.17912/micropub.biology.001354

Dietary B vitamins influence the Drosophila melanogaster preference for dietary yeast

MicroPubl Biol. 2024 Dec 5:2024:10.17912/micropub.biology.001354. doi: 10.17912/micropub.biology.001354. eCollection 2024.

Authors

Dean B Peterson¹, John Chaston¹, Andrew T Call¹

Affiliation

¹ Department of Plant and Wildlife Sciences, Brigham Young University, Provo, UT, United States.

Abstract

The microbiota influences the Drosophila melanogaster dietary preference for yeast (DPY). We previously identified four transposon insertion mutants in Acetobacter fabarum that significantly influence fly DPY, and three of these insertions were in genes that are associated with thiamine metabolism. Here, we tested if thiamine influences fly DPY in monoassociated flies. We show that thiamine and other B vitamins influence fly DPY and that the different mutants have distinct DPY responses to thiamine supplementation. Together, these experiments identify specific nutritional effectors of D. melanogaster DPY.

Grants and funding

Research reported in this publication was supported in part by the National Institute of General Medical Sciences of the National Institutes of Health under Award Number R15GM140388. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Additional support was received from the Brigham Young University College of Undergraduates Research Award.