Humoral response 24 months after the first COVID-19 vaccination in people with HIV with and without diabetes

Louise Bering; Line Dam Heftdal; Safura-Luise Heidari; Sebastian Rask Hamm; Cecillie Bo Hansen; Dina Leth Møller; Mia Pries-Heje; Kamille Fogh; Rasmus Bo Hasselbalch; Laura Pérez-Alós; Jan Gerstoft; Thomas Benfield; Selina Kikkenborg Berg; Anne Vinggaard Christensen; Nina Marie Birk; Linda Maria Hilsted; Sisse Rye Ostrowski; Ruth Frikke-Schmidt; Erik Sørensen; Kirsten Grønbæk; Henning Bundgaard; Kasper Iversen; Peter Garred; Susanne Dam Nielsen

doi:10.1097/QAD.0000000000004026

Humoral response 24 months after the first COVID-19 vaccination in people with HIV with and without diabetes

AIDS. 2024 Dec 1;38(15):2100-2103. doi: 10.1097/QAD.0000000000004026. Epub 2024 Nov 14.

Authors

Louise Bering¹, Line Dam Heftdal^{1

2}, Safura-Luise Heidari¹, Sebastian Rask Hamm¹, Cecillie Bo Hansen³, Dina Leth Møller¹, Mia Pries-Heje⁴, Kamille Fogh⁵, Rasmus Bo Hasselbalch⁵, Laura Pérez-Alós³, Jan Gerstoft^{1

6}, Thomas Benfield^{6

7}, Selina Kikkenborg Berg^{4

6}, Anne Vinggaard Christensen⁴, Nina Marie Birk⁴, Linda Maria Hilsted⁸, Sisse Rye Ostrowski^{3

6}, Ruth Frikke-Schmidt^{6

8}, Erik Sørensen³, Kirsten Grønbæk^{2

6

9}, Henning Bundgaard^{4

6}, Kasper Iversen^{5

6

10}, Peter Garred^{3

6}, Susanne Dam Nielsen^{1

6

11}

Affiliations

¹ Viro-Immunology Research Unit, Department of Infectious Diseases.
² Department of Hematology.
³ Department of Clinical Immunology.
⁴ Department of Cardiology, Copenhagen University Hospital Rigshospitalet.
⁵ Department of Cardiology, Copenhagen University Hospital Herlev and Gentofte Hospital.
⁶ Department of Clinical Medicine, University of Copenhagen, Copenhagen.
⁷ Department of Infectious Diseases, Copenhagen University Hospital Amager and Hvidovre, Hvidovre.
⁸ Department of Clinical Biochemistry, Copenhagen University Hospital Rigshospitalet.
⁹ Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen.
¹⁰ Department of Emergency Medicine, Copenhagen University Hospital Herlev and Gentofte Hospital, Herlev.
¹¹ Department of Surgical Gastroenterology and Transplantation, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

PMID: 39715497
DOI: 10.1097/QAD.0000000000004026

Abstract

People with HIV (PWH) and people with diabetes mellitus have increased risk of severe COVID-19, but little is known about humoral response to COVID-19 vaccines in PWH with DM. We investigated SARS-CoV-2 antireceptor-binding domain (anti-RBD) immunoglobulin G (IgG) geometrical concentrations and neutralizing antibody capacity (nAB) in PWH with and without diabetes mellitus. Anti-RBD IgG and nAB in COVID-19-vaccinated PWH were not associated with diabetes mellitus-status or HbA1c 24 months after the initial COVID-19 vaccination.

MeSH terms

Adult
Aged
Antibodies, Neutralizing* / blood
Antibodies, Neutralizing* / immunology
Antibodies, Viral* / blood
COVID-19 Vaccines* / administration & dosage
COVID-19 Vaccines* / immunology
COVID-19* / complications
COVID-19* / immunology
COVID-19* / prevention & control
Diabetes Mellitus / immunology
Female
HIV Infections* / complications
HIV Infections* / immunology
Humans
Immunity, Humoral*
Immunoglobulin G* / blood
Immunoglobulin G* / immunology
Male
Middle Aged
SARS-CoV-2* / immunology
Vaccination

Substances

COVID-19 Vaccines
Antibodies, Neutralizing
Antibodies, Viral
Immunoglobulin G