Purpose: To determine the predictive value of the atherogenic index of plasma before transplant for delayed graft function.
Patients and methods: A cross-sectional, longitudinal, non-interventional, non-controlled study of 167 patients undergoing kidney transplantation from living donors, with a mean age of 39.34 ± 11.86 years old, 53.3% male, and a pre-transplant hemodialysis time of 14 (7-36) months. Delayed graft function was defined as decreased blood creatinine < 25% within the first 24 h compared to pre-transplantation, and the patients needed hemodialysis in the first 7 days. The atherogenic index of plasma was calculated based on pre-transplant plasma triglycerides and high-density lipoprotein cholesterol concentrations.
Results: The ratio of delayed graft function in renal transplant recipients from living donors was 13.8% (23/167 patients). Hemodialysis time, the ratio of hepatitis infection, overweight and obese, atherosclerosis, positive PRA, and acute rejection in the DGF (+) group were higher than those of the DGF (-) group, p < 0.05 and < 0.001. In particular, plasma CRP-hs level and AIP also were higher in DGF (+) patients compared to those of DGF (-) ones, p < 0.001. Long hemodialysis time, obesity, high plasma CRP-hs, and high AIP in pre-transplant patients were independent factors related to DGF and had predictive value for DGF after kidney transplantation, in which AIP had good predictive value: AUC = 0.859, p < 0.001.
Conclusion: Delayed graft function was relatively common in renal transplant recipients from living donors. AIP before kidney transplant was a good predictor for delayed graft function.
Keywords: atherogenic index of plasma; delayed graft function; kidney transplantation; living donor.
© 2024 The Author(s). Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC.