Long-term outcomes of pediatric temporal bone fractures with hearing loss: Results of a multinational database analysis

Jason L Steele; Heather J Smith; Samira Takkoush; Jumah G Ahmad; Zachary D Urdang; Neil S Patel; Richard K Gurgel; Mana Espahbodi

doi:10.1016/j.ijporl.2024.112186

Long-term outcomes of pediatric temporal bone fractures with hearing loss: Results of a multinational database analysis

Int J Pediatr Otorhinolaryngol. 2024 Dec 15:188:112186. doi: 10.1016/j.ijporl.2024.112186. Online ahead of print.

Authors

Jason L Steele¹, Heather J Smith², Samira Takkoush³, Jumah G Ahmad³, Zachary D Urdang⁴, Neil S Patel³, Richard K Gurgel³, Mana Espahbodi⁵

Affiliations

¹ University of Utah, Department of Otolaryngology - Head & Neck Surgery, United States; Rocky Vista University College of Osteopathic Medicine, United States.
² University of Utah, Department of Otolaryngology - Head & Neck Surgery, United States; University of Utah, Spencer Fox Eccles School of Medicine, United States.
³ University of Utah, Department of Otolaryngology - Head & Neck Surgery, United States.
⁴ University of Iowa, Department of Otolaryngology - Head & Neck Surgery, United States.
⁵ University of Utah, Department of Otolaryngology - Head & Neck Surgery, United States. Electronic address: mana.espahbodi@hsc.utah.edu.

PMID: 39721303
DOI: 10.1016/j.ijporl.2024.112186

Abstract

Introduction: Pediatric temporal bone fractures (TBFs) can result in adverse outcomes including meningitis, significant sensorineural hearing loss requiring cochlear implantation (CI), facial nerve weakness, cerebrospinal fluid (CSF) leak, and labyrinthitis. The objective of this study is to determine the risks of these outcomes for TBFs with hearing loss.

Methods: Using the multinational TriNetX database, a retrospective cohort study was performed of patients less than 18 years old with diagnostic codes for other fracture of base of skull and hearing loss to serve as an approximation of TBF. This classification excluded all TBFs without hearing loss. An age- and sex-matched control cohort was selected without the above-mentioned diagnostic codes. More than 95 % of patient data used is from 2006-present, with an average of 12-14 years of data per health care organization. Measured outcomes included meningitis, CI, facial nerve disorders (including facial nerve weakness, lagophthalmos, and eyelid weight placement for lagophthalmos), CSF leak and labyrinthitis after TBF. Risk ratios were calculated after 1:1 propensity-score matching (PSM) for age and sex.

Results: TriNetX identified 2739 pediatric patients (mean age of 7.61 ± 4.39 years) with TBF and an age- and sex-matched cohort of 2739 pediatric patients without TBF (mean age of 7.58 ± 4.37 years). Those with TBF had a greater risk of developing meningitis (RR: 2.90, 95 % CI: 1.42-5.94) and facial nerve disorders (RR: 13.44, 95 % CI: 8.83-20.45) at any time than those without TBF. Matched results were not available for labyrinthitis, CI or CSF leak, as there were multiple instances in the Pediatric TBF cohort versus zero instances in the Control cohort. Results prior to PSM demonstrated an increased risk for labyrinthitis (RR: 43.12, 95 % CI: 23.17-80.27), CI (RR: 21.61, 95 % CI: 13.03-35.84) and CSF leak (89.08, 95 % CI: 67.71-117.20) in the pediatric TBF cohort compared with the cohort without TBF.

Discussion: Pediatric patients who sustain TBF with hearing loss are at increased risk of subsequent meningitis and facial nerve disorders and may also be at increased risk of labyrinthitis, CSF leak, and undergoing CI.

Published by Elsevier B.V.