Triptophenolide Improves Rheumatoid Arthritis and Progression by Inducing Macrophage Toxicity

J Biochem Mol Toxicol. 2025 Jan;39(1):e70096. doi: 10.1002/jbt.70096.

Abstract

To investigate the role and mechanism of triptophenolide (TRI) in resisting rheumatoid arthritis (RA). Network pharmacology analysis results suggested that TRI was related to multiple inflammation-related signaling proteins, and possessed the stable structural configuration. In animal experiments, TRI suppressed RA in mice, inhibited tissue inflammation, and improved synovial injury. Moreover, TRI can suppress RA via multiple signaling pathways, and inhibiting pyroptosis is one of the feasible treatments for improving RA.

Keywords: network pharmacology; pyroptosis; rheumatoid arthritis; triptophenolide.

MeSH terms

  • Animals
  • Arthritis, Experimental / chemically induced
  • Arthritis, Experimental / drug therapy
  • Arthritis, Experimental / pathology
  • Arthritis, Rheumatoid* / drug therapy
  • Arthritis, Rheumatoid* / pathology
  • Humans
  • Macrophages* / drug effects
  • Macrophages* / metabolism
  • Male
  • Mice
  • Signal Transduction / drug effects
  • Triterpenes

Substances

  • triptonide
  • Triterpenes