Natural polysaccharide hydrogel delivery system remodeling tumor microenvironment to promote postoperative tumor therapy

Xin Liu; Yumei Wang; Han Wu; Dayang Wang; Huanchen Yao; Zekai Ren; Yang Cao; Hailin Cong; Bing Yu

doi:10.1016/j.ijbiomac.2024.139137

Natural polysaccharide hydrogel delivery system remodeling tumor microenvironment to promote postoperative tumor therapy

Int J Biol Macromol. 2024 Dec 24:139137. doi: 10.1016/j.ijbiomac.2024.139137. Online ahead of print.

Authors

Xin Liu¹, Yumei Wang¹, Han Wu¹, Dayang Wang¹, Huanchen Yao¹, Zekai Ren¹, Yang Cao¹, Hailin Cong², Bing Yu³

Affiliations

¹ College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Institute of Biomedical Materials and Engineering, Qingdao University, Qingdao 266071, China.
² College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Institute of Biomedical Materials and Engineering, Qingdao University, Qingdao 266071, China; State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao 266071, China; School of Materials Science and Engineering, Shandong University of Technology, Zibo 255000, China. Electronic address: conghailin@sdut.edu.cn.
³ College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Institute of Biomedical Materials and Engineering, Qingdao University, Qingdao 266071, China; State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao 266071, China. Electronic address: yubing198@qdu.edu.cn.

PMID: 39725109
DOI: 10.1016/j.ijbiomac.2024.139137

Abstract

In recent years, postoperative tumor therapy with a suitable approach has been an important issue. Remodeling the tumor microenvironment and accelerating tissue repair can accelerate patients' surgical site recovery, reduce patient pain as well as prevent postoperative tumor recurrence. The shape non-adaptability, cytotoxicity, and non-degradability of some hydrogels still hinder the application of hydrogel-based drug delivery systems in postoperative recovery. Natural polysaccharides (e.g., chitosan, sodium alginate, and hyaluronic acid) are multifunctional compounds with biomimetic advantages to meet the growing demand for nontoxic, targeted therapeutic, and restorative preventive therapies. In this paper, we comprehensively and systematically investigated the synthesis methods, properties, and applications of natural polysaccharide hydrogel (NPH) delivery systems, as well as the mechanisms of remodeling the tumor microenvironment. We aim to provide insights into the design of NPH delivery systems. On this basis, future research directions for NPH delivery systems and their role in remodeling the tumor microenvironment and accelerating postoperative tumor therapy are proposed, and strategies for remodeling the tumor microenvironment using hydrogel delivery systems are discussed, as well as the latest research methods.

Keywords: Drug delivery systems; Natural polysaccharide hydrogel; Polysaccharide classification; Tissue repair mechanisms; Tumor treatment.

Publication types

Review