Ecotoxicity of Biodegradable Microplastics and Bio-based Microplastics: A Review of in vitro and in vivo Studies

Kuok Ho Daniel Tang; Jian Zhou

doi:10.1007/s00267-024-02106-w

Ecotoxicity of Biodegradable Microplastics and Bio-based Microplastics: A Review of in vitro and in vivo Studies

Environ Manage. 2024 Dec 27. doi: 10.1007/s00267-024-02106-w. Online ahead of print.

Authors

Kuok Ho Daniel Tang¹, Jian Zhou²

Affiliations

¹ Department of Environmental Science, The University of Arizona, Tucson, Arizona, 85721, USA. danielkhtang@arizona.edu.
² College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi Province, 712100, PR China.

PMID: 39730878
DOI: 10.1007/s00267-024-02106-w

Abstract

As biodegradable and bio-based plastics increasingly replace conventional plastics, the need for a comprehensive understanding of their ecotoxicity becomes more pressing. This review systematically presents the ecotoxicity of the microplastics (MPs) from different biodegradable plastics and bioplastics on various animals and plants. High doses of polylactic acid (PLA) MPs (10%) have been found to reduce plant nitrogen content and biomass, and affect the accumulation of heavy metals in plants. Their phytotoxicity becomes more pronounced when blended with polybutylene adipate terephthalate (PBAT) MPs. Polyhydroxybutyrate (PHB) and polybutylene succinate (PBS) MPs show lower phytotoxicity than PLA MPs. At high doses, PLA and PHB MPs may cause dose-dependent developmental toxicity to aquatic organisms. Nano-PLA could induce oxidative stress and genetic damage in insects, indicating its toxicity could be size-dependent and affected by weathering. PBAT MPs have been observed to affect plant growth at lower concentrations (0.1%) than PLA MPs, while polycaprolactone (PCL) affected seed germination only at high temperatures. PCL MPs and extracts could also cause developmental and reproductive toxicity, alter metabolisms, and induce oxidative stress in aquatic organisms at high concentrations. Polypropylene carbonate (PPC) ( > 40 g/kg) MPs have caused earthworm behavioral changes. Non-biodegradable bioplastics are potentially toxic to embryos, larvae, immune systems, reproductive systems, and endocrine systems of animals. However, it is important to note that toxicity studies are still lacking for biodegradable and bio-based plastics, particularly PHB, PBS, PCL, PPC, starch-based, and non-biodegradable bioplastics. More research into the MPs of these plastics is essential to better understand their ecotoxicity and applicability.

Keywords: Biodegradable; Microplastics; Oxidative stress; Polybutyleneadipate terephthalate; Polylactic acid; Toxicity.